New maleimide 1,2,3-triazole hybrids: design, synthesis, anticancer, and antimicrobial activities

Salameh, Bader A.; Safieh, Kayed A. Abu; Al-Hushki, Eman H.; Talib, Wamidh H.; Al-ataby, Israa A.; Al‐Qawasmeh, Raed A.

doi:10.1007/s00706-020-02685-4

Cited by 8 publications

(1 citation statement)

References 23 publications

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“…Thiazine nucleus is being studied as a potential pharmaceutical molecule to be employed in therapeutics treatments of Alzheimer’s disease, cancer, diabetes, and others ( Choudhary & Silakari, 2018 ). Maleimide is also a precursor of several other compounds with anti-fungal, anti-microbial, anti-bacterial, and anti-cancer actions ( Salameh et al, 2020 ). These findings also may be associated with the longevity reported by caferana seeds consumers ( Fraga et al, 2020 , Peixoto et al, 2017 ).…”

Section: Resultsmentioning

confidence: 99%

Caferana seeds (Bunchosia glandulifera) as a new source of nutrients: Evaluation of the proximal composition, solvent extraction, bioactive compounds, and δ-lactam isolation

et al. 2021

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Section: Resultsmentioning

confidence: 99%

Caferana seeds (Bunchosia glandulifera) as a new source of nutrients: Evaluation of the proximal composition, solvent extraction, bioactive compounds, and δ-lactam isolation

et al. 2021

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Substituted Maleimides: Self‐Reportable Linkers and Tags in Bioconjugation, Materials Science, and Nanotechnology

Barker,

Tibbetts,

Ferguson

et al. 2024

Angewandte Chemie

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Substituted maleimides are customisable fluorescent linkers and probes with adaptable reactivity and optical properties. Their compact nature and tunability has led to their use in various applications. For example, their solvatochromic properties offer real‐time feedback on linking chemistry and environmental changes, essential for applications in material labelling, drug delivery, and nanoparticle functionalization. This review focuses on developing, synthesising, and modifying substituted maleimides as environment‐sensitive fluorescent linkers and probes. It delves into their photophysical dynamics and strategic applications, highlighting their significant contributions to macromolecule conjugation and the development of self‐reporting materials.

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1,2,3‐Triazole hybrids as anticancer agents: A review

Alam

2021

Archiv der Pharmazie

189

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Despite the advancements in the development of anticancer agents, more effective and safer anticancer drugs still need to be developed as the current agents cause unwanted side effects and many patients have become drug resistant. 1,2,3-Triazoles, due to their remarkable biological potential, have received considerable attention in drug discovery for the development of anticancer agents. The present review article presents an overview of the recent advances in 1,2,3-triazole hybrids with anticancer potential over the last 2 years, their chemical structures, structure-activity relationships, and mechanisms of action, as well as insights into the docking studies.

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New maleimide 1,2,3-triazole hybrids: design, synthesis, anticancer, and antimicrobial activities

Cited by 8 publications

References 23 publications

Caferana seeds (Bunchosia glandulifera) as a new source of nutrients: Evaluation of the proximal composition, solvent extraction, bioactive compounds, and δ-lactam isolation

Caferana seeds (Bunchosia glandulifera) as a new source of nutrients: Evaluation of the proximal composition, solvent extraction, bioactive compounds, and δ-lactam isolation

Substituted Maleimides: Self‐Reportable Linkers and Tags in Bioconjugation, Materials Science, and Nanotechnology

1,2,3‐Triazole hybrids as anticancer agents: A review

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