New marine natural products from sponges (Porifera) of the order Dictyoceratida (2001 to 2012); a promising source for drug discovery, exploration and future prospects

Mehbub, Mohammad F.; Perkins, Michael V.; Zhang, Wei; Franco, Christopher M. M.

doi:10.1016/j.biotechadv.2015.12.008

Cited by 65 publications

(47 citation statements)

References 253 publications

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“…Marine invertebrates in particular have proven to be major sources of MNPs in clinical trials [ 20 ]. Also, mounting evidence suggests that many of the compounds originally associated with the biomass of macroorganisms such as sponges [ 21 ], tunicates [ 22 ], molluscs [ 23 ] amongst others, are not produced by the organism itself but are synthesized by symbiotic or associated microorganisms, or derive from a diet of prokaryotic microorganisms [ 24 ]. Unlike the terrestrial environment, where plants are comparatively richer in secondary metabolites, marine invertebrates and bacteria have yielded substantially more bioactive natural products than marine plants [ 25 ].…”

Section: Marine Natural Products (Mnps)mentioning

confidence: 99%

Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials

et al. 2017

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The marine environment is a rich source of chemically diverse, biologically active natural products, and serves as an invaluable resource in the ongoing search for novel antimicrobial compounds. Recent advances in extraction and isolation techniques, and in state-of-the-art technologies involved in organic synthesis and chemical structure elucidation, have accelerated the numbers of antimicrobial molecules originating from the ocean moving into clinical trials. The chemical diversity associated with these marine-derived molecules is immense, varying from simple linear peptides and fatty acids to complex alkaloids, terpenes and polyketides, etc. Such an array of structurally distinct molecules performs functionally diverse biological activities against many pathogenic bacteria and fungi, making marine-derived natural products valuable commodities, particularly in the current age of antimicrobial resistance. In this review, we have highlighted several marine-derived natural products (and their synthetic derivatives), which have gained recognition as effective antimicrobial agents over the past five years (2012–2017). These natural products have been categorized based on their chemical structures and the structure-activity mediated relationships of some of these bioactive molecules have been discussed. Finally, we have provided an insight into how genome mining efforts are likely to expedite the discovery of novel antimicrobial compounds.

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Section: Marine Natural Products (Mnps)mentioning

confidence: 99%

Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials

et al. 2017

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“…Pencarian obat baru dengan mode of action yang baru adalah salah satu solusi untuk mengatasi permasalahan pathogen MDR. Banyak sumber daya laut dikembangkan untuk mencari antibakteri alami dari sponge (Mehbub et al, 2016) Sponge adalah salah satu biota laut yang paling potensial sebagai sumber senyawa antibakteri. Senyawa bioaktif sponge dihasilkan oleh metabolit sekunder yang dimanfaatkan sebagai bahan obatobatan, misalnya antibakteri, antitumor, antikanker, antijamur, anti-inflamantori, sitotoksik, antimikroba, antivirus, antimalaria, antifauling, dan immunosupresif (Mayer et al, 2009).…”

Section: Saat Ini Banyak Ditemukan Bakteriunclassified

Skrining Aktivitas Antibakteri Dan Identifikasi Sponge Dari Teluk Kupang

et al. 2016

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Recently, many research proved that bacteria Escherichia coli and Staphylococus aureus have resistant to antibiotics, called Multi Drug Resistance (MDR). The bacteria cause various diseases both in humans and animals. Exploration and development of new antibiotics is needed, one which is derived from a sea sponge. This research aims to determine the potential of antibacterial sponge extracts from the waters of Kupang, East Nusa Tenggara against E. coli and S. aureus MDR, as well as being able to identify the sponge. Maceration method was employed on extraction of the sponges, then the extract were tested against E. coli and S. aureus. The extracts content of sponge varied from 0.4% to 5,19%. Anti bacterial test showed that the sponge K14-52 has the highest inhibition zone of 10,43 ± 0,26 mm and 9,38 ± 0,57 mm and against the E. coli and S. Aureus, respectively, at a concentration of 500 ug/disk. Based on macroscopic and microscopic anayses, the K14-52 sponge is identified as Rhabdastrella globostellata. a Demospongia sponge. The sponge has special characteristic i.e. globular shape with large oscula on the top of the sponge and ostia along the surface. The sponge also characterized with makrosclera monoaxon spikule (hastate oxea, centrotylote oxea, oxea fusiform gyrus) and mikrosclera tertaxon oxyaster spikule. Keywords: Antibacterial, Sponges, Staphylococcus aureus, Escherichia coli Saat ini banyak ditemukan bakteri Escherichia coli dan Staphylococus aureus yang resisten terhadap antibiotik atau disebut Multi Drugs Resistance (MDR). Bakteri tersebut dapat menimbulkan berbagai penyakit baik pada manusia maupun hewan. Eksplorasi dan pengembangan sumber antibiotik baru sangat diperlukan, salah satunya yang berasal dari sponge laut. Penelitian ini bertujuan untuk mengetahui potensi antibakteri ekstrak sponge dari Perairan Kupang, Nusa Tenggara Timur terhadap bakteri E. coli dan S. aureus MDR, serta mampu mengetahui jenis sponge. Ekstraksi dilakukan dengan metoda maserasi kemudian ekstrak diuji terhadap bakteri patogen. Uji antibakteri menunjukkan bahwa sponge K14-52 memiliki potensi antibakteri paling tinggi dengan zona hambat sebesar 10,43±0,26 mm terhadap bakteri E. coli dan 9,38±0,57 mm terhadap bakteri S. aureus pada konsentrasi 500 µg/disk. Sponge K14-52 diidentifikasi sebagai Rhabdastrella globostellata berdasarkan analisis secara makroskopis dan mikroskopis. Ciri khas sponge tersebut adalah mempunyai bentuk bulat dengan ostia yang tersebar pada permukaan dan satu Oskula besar pada bagian atas sponge. Secara mikroskopis sponge tersebut memiliki makrosklera monoaxon spikula (hastate oxea, centrotylote oxea, fusiform oxea) dan mikrosklera tertaxon spikula Oxyaster. Kata kunci: Antibakteri, Sponge, Identifikasi Sponge

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“…Natural products continue to offer a productive source of structural diversity and bioactivity, and are an important source for new drugs. 3–4, 6–7…”

Section: Introductionmentioning

confidence: 99%

Discovery of antimicrobial compounds from Lendenfeldia, Ircinia and Dysidea sponges using bioassay guided fractionation of marine extracts

Dinarvand

Proschogo

Spain

et al. 2018

Preprint

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Multidrug resistant bacteria have emerged as a threat to public health all over the world. At the same time, the discovery of new bioactive small molecules with antimicrobial activity and suitable pharmacological properties has waned. Herein we report the screening of marine extracts to identify novel compounds with antimicrobial activity. Bioassay guided fractionation has enabled the discovery and identification of a family of simple amines with promising activity against methicillin resistant Staphylococcus aureus (MRSA). To confirm the natural product structures proposed, these compounds and analogues have been prepared synthetically. Several of the synthetic analogues showed promising bioactivity against the medically important pathogens MRSA (MICs to 12.5 µM), Mycobacterium tuberculosis (MICs to 0.02 µM), uropathogenic Escherichia coli (MIC 6.2 µM) and Pseudomonas aeruginosa (MIC 3.1 µM). Cross-referencing antimicrobial activity and toxicity show that these synthetic compounds display a favourable therapeutic index for their target pathogens.

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New marine natural products from sponges (Porifera) of the order Dictyoceratida (2001 to 2012); a promising source for drug discovery, exploration and future prospects

Cited by 65 publications

References 253 publications

Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials

Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials

Skrining Aktivitas Antibakteri Dan Identifikasi Sponge Dari Teluk Kupang

Discovery of antimicrobial compounds from Lendenfeldia, Ircinia and Dysidea sponges using bioassay guided fractionation of marine extracts

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