New mechanisms involved in the development of cardiovascular disease in chronic kidney disease

Figuer, Andrea; Alique, Matilde; Valera, G. Guerra; Serroukh, Nadia; Ceprián, Noemí; Sequera, Patricia de; Morales, Enrique; Carracedo, Julia; Ramı́rez, Rafael; Bodega, Guillermo

doi:10.1016/j.nefroe.2023.05.014

Cited by 7 publications

(4 citation statements)

References 116 publications

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“…Different conditions such as diabetes mellitus, atherosclerosis, hypertension, endothelial dysfunction, and impaired angiogenesis contribute to microvascular dysfunction [11], [19]. It has been demonstrated that markers of endothelial dysfunction and angiogenesis markers have been predictors of disease severity in heart failure, renal failure, and after cardiac surgery [20], [21]. These biomarkers circulate in the blood and can cause and affect microvascular dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Angiopoietins as Predictor Indexes in COVID-19 Patients in Delta and Omicron Waves

Tsiatsiou,

Kouirouxis,

Tsaireli

et al. 2024

Preprint

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The study aimed to explore the correlation among Angiopoietin-1, (Ang-1) and Angiopoietin-2, (Ang-2) concentrations and the Angiopoietin-2/Angiopoietin-1 ratio, (Ang-2/Ang-1) with clinical outcomes, potentially serving as disease severity and survival biomarkers. A study at AHEPA University Hospital involved 90 COVID-19 adult patients, with 30 hospitalized in intensive care and 30 in ward units and 30 asymptomatic non-hospitalized individuals as controls. Estimated endothelial dysfunction markers related to angiogenesis were measured, and statistical analysis was performed using IBM SPSS Statistics software, version 29. There was a statistically significant difference only between outpatient and hospitalized patients (non-ICU -ICU groups) for the Ang-1 and Ang-2 indexes. The Ang-2/Ang-1 ratio has differed significantly among all individual patient groups. A ROC analysis was conducted to find an optimal threshold for distinguishing (outpatients – non-ICU) and (non-ICU –ICU) groups. It was based on Youden's Index and was 0.1122 and 0.3825, respectively. The Ang-1, Ang-2 levels, and Ang-2/Ang-1 ratio were analysed as indicators for severity in COVID-19 patients. The Ang-2/Ang-1 ratio demonstrated more excellent prognostic and diagnostic utility than individual biomarker levels. Monitoring the Ang-2/Ang-1 ratio can identify COVID-19 patients at risk and assist clinicians in tailoring treatment strategies for improved outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Angiopoietins as Predictor Indexes in COVID-19 Patients in Delta and Omicron Waves

Tsiatsiou,

Kouirouxis,

Tsaireli

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Different conditions, such as diabetes mellitus, atherosclerosis, hypertension, endothelial dysfunction, and impaired angiogenesis, contribute to microvascular dysfunction [11,19]. It has been demonstrated that markers of endothelial dysfunction and angiogenesis are predictors of disease severity in heart failure, renal failure, and after cardiac surgery [20,21]. These biomarkers circulate in the blood and can cause and affect microvascular dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Angiopoietins as Predictor Indexes in COVID-19 Patients in Delta and Omicron Waves

Tsiatsiou,

Kouirouxis,

Tsaireli

et al. 2024

CIMB

View full text Add to dashboard Cite

This study aimed to explore the correlation between Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) concentrations and the Angiopoietin-2/Angiopoietin-1 ratio (Ang-2/Ang-1) with clinical outcomes, potentially serving as disease severity and survival biomarkers. A study at AHEPA University Hospital involved 90 Coronavirus Disease 2019 (COVID-19) adult patients, 30 hospitalized intensive care units (ICU), 30 inward units (non-ICU), and 30 asymptomatic non-hospitalized individuals as controls. Estimated endothelial dysfunction markers related to angiogenesis were measured. There was a statistically significant difference only between outpatient and hospitalized patients (non-ICU–ICU groups) for the Ang-1 and Ang-2 indices. The Ang-2/Ang-1 ratio has differed significantly among the individual patient groups. An ROC analysis was conducted to find an optimal threshold for distinguishing between (outpatients–non-ICU) and (non-ICU–ICU) groups. It was based on Youden’s index of 0.1122 and 0.3825, respectively. The Ang-1, Ang-2 levels, and Ang-2/Ang-1 ratio were analyzed as severity indicators in COVID-19 patients. The Ang-2/Ang-1 ratio demonstrated better prognostic and diagnostic utility than individual biomarker levels. Monitoring the Ang-2/Ang-1 ratio can identify COVID-19 patients at risk and assist clinicians in tailoring treatment strategies to improve outcomes.

show abstract

“…Different conditions such as diabetes mellitus, atherosclerosis, hypertension, endothelial dysfunction, and impaired angiogenesis contribute to microvascular dysfunction [10], [17]. It has been demonstrated that markers of endothelial dysfunction and angiogenesis markers have been predictors of disease severity in heart failure, renal failure, and after cardiac surgery [18], [19] These biomarkers circulate in the blood and can cause and effect microvascular dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Angiopoietins as Predictor Indexes in COVID COVID-19 Patients in Delta and Omicron Waves

Tsiatsiou,

Kouirouxis,

Tsaireli

et al. 2023

Preprint

View full text Add to dashboard Cite

The study aimed to explore the correlation among angiopoietin-1, (Ang-1) and Angiopoietin-2, (Ang-2) concentrations and the Angiopoietin-2/Angiopoietin-1 ratio, (Ang-2/Ang-1) with clinical outcomes, potentially serving as disease severity and survival biomarkers. A study at AHEPA University Hospital involved 90 COVID-19 adult patients, with 30 hospitalized in intensive care and 30 in ward units and 30 asymptomatic non-hospitalized individuals as controls. Estimated endothelial dysfunction markers related to angiogenesis were measured, and statistical analysis was performed using IBM SPSS Statistics software, version 29. There was a statistically significant difference only between outpatient and hospitalized patients (non-ICU -ICU groups) for the Ang-1 and Ang-2 indexes. The Ang-2/Ang-1 ratio has differed significantly among all individual patient groups. A ROC analysis was conducted to find an optimal threshold for distinguishing (outpatients – non-ICU) and (non-ICU – ICU) groups. It was based on Youden's Index and was 0.1122 or 0.1271 and 0.3825 or 0.4510, respectively. The Ang-1, Ang-2 levels, and Ang-2 / Ang-1 ratio were analysed as indicators for severity in COVID-19 patients. The Ang-2 / Ang-1 ratio demonstrated more excellent prognostic and diagnostic utility than individual biomarker levels. Monitoring the Ang-2/Ang-1 ratio can identify COVID-19 patients at risk and assist clinicians in tailoring treatment strategies for improved outcomes.

show abstract

New mechanisms involved in the development of cardiovascular disease in chronic kidney disease

Cited by 7 publications

References 116 publications

Angiopoietins as Predictor Indexes in COVID-19 Patients in Delta and Omicron Waves

Angiopoietins as Predictor Indexes in COVID-19 Patients in Delta and Omicron Waves

Angiopoietins as Predictor Indexes in COVID-19 Patients in Delta and Omicron Waves

Angiopoietins as Predictor Indexes in COVID COVID-19 Patients in Delta and Omicron Waves

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