New Method for Fabrication of Loaded Micro- and Nanocontainers:  Emulsion Encapsulation by Polyelectrolyte Layer-by-Layer Deposition on the Liquid Core

Abstract

A novel approach to the emulsion encapsulation was developed by combining the advantages of direct encapsulation of a liquid colloidal core with the accuracy and multifunctionality of layer-by-layer polyelectrolyte deposition. Experimental data obtained for the model oil-in-water emulsion confirm unambiguously the alternating PE assembly in the capsule shell as well as the maintenance of the liquid colloidal core. Two different mechanisms of capsule destruction upon interaction with the solid substrate were observed and qualitatively explained. The proposed method can be easily generalized to the preparation of oil-filled capsules in various oil/water/polyelectrolyte systems important in the field of pharmacy, medicine, and food industry.

Polymeric Multilayer Capsules in Drug Delivery

“…The easiest way to disperse an immiscible phase into a continuous phase is through the formation of droplets by high-speed shearing or sonication of the mixture. The resulting emulsions have a rather broad size distribution [81] and can be subjected to further homogenization. [82,83] More recently, microfluidic emulsification has emerged as the most straightforward method to generate monodisperse emulsions.…”

Wirkstoffverabreichung mithilfe polymerer Mehrschichtkapseln

“…Am einfachsten lässt sich ein Stoff, der mit einer kontinuierlichen Phase nicht mischbar ist, durch hohe Scherkräfte oder Ultraschalleinwirkung darin dispergieren. Die Tröpfchen in den erhaltenen Emulsionen weisen eine ziemlich breite Größenverteilung auf, [81] die Emulsion kann aber weiter homogenisiert werden. [82,83] In neuerer Zeit hat sich das Mikrofluid-Emulgieren als das einfachste Verfahren zur Herstellung monodisperser Emulsionen herausgestellt.…”

“…Um die mehrfache Beschichtung der Tröpfchen zu erleichtern, ist ein ionisches Detergens zu bevorzugen, das den Tröpfchen eine hinreichende Oberflächenladung verleiht. Es wurde über Proteine, [85] kationische [81,86] und anionische Lipide [82] sowie amphiphile Polymere [86] [67] C) Laserinduziertes Mischen der Bestandteile beider Kompartimente der PMLCs. Die inneren und äußeren Hüllen sind schematisch durch schwarze Kreise wiedergegeben.…”

Investigation of Click Reaction at an Oil-Water Interface Using Hydrophobic and Hydrophilic Polymers

“…Stoddart and co-workers 7 have reported a unique selective click reaction at a liquid-solid interface induced by catalysis on the apex of an atomic force microscope tip. Polymer thin films prepared by layer-by-layer techniques at emulsion 8 and macroscopic L/L interfaces 9 have also been reported. Rotello and coworkers 6 International Letters of Chemistry, Physics This work was motivated by recent reports demonstrating methods for the fabrication of nanofilms, hollow microcapsules and gel.…”