New method for perfusing bronchial arteries: histamine bronchoconstriction and apnea.

DeKock, M; Ja, Nadel; S, Zwi; Colebatch, H. J. H.; Olsen, C. Robert

doi:10.1152/jappl.1966.21.1.185

Cited by 146 publications

(57 citation statements)

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“…Rapid expiratory maneuvers had similar effects. Both rapid inspiration and rapid expiration stimulate cough receptors, particularly when these receptors have been "sensitized" by infection or by inhalation of ammonia gas (4 (20). That study also indicated that the afferent pathways were in the pulmonary vagi.…”

Section: Discussionmentioning

confidence: 83%

Role of Autonomic Nervous System and the Cough Reflex in the Increased Responsiveness of Airways in Patients with Obstructive Airway Disease*

Simonsson¹,

Jacobs²,

Nadel³

1967

J. Clin. Invest.

352

148

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Abstract. Inhalation of aerosols of citric acid, histamine phosphate, or carbon dust, or air cooled to -20'C or rapid respiratory maneuvers (inspiration or expiration) results in an increase in airway resistance in some patients with asthma or bronchitis. It has been shown previously in animals that stimulation of cough receptors results in bronchoconstriction through efferent cholinergic pathways. In the patients studied, the administration of atropine sulfate, which would block such pathways, abolished the bronchoconstrictor effects of all the stimuli except large doses of histamine, which may exert a direct effect on airway smooth muscle. These data suggest that sensitized cough receptors may be involved in triggering reflex airway constriction in such patients.

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Section: Discussionmentioning

confidence: 83%

Role of Autonomic Nervous System and the Cough Reflex in the Increased Responsiveness of Airways in Patients with Obstructive Airway Disease*

Simonsson¹,

Jacobs²,

Nadel³

1967

J. Clin. Invest.

352

148

View full text Add to dashboard Cite

show abstract

“…The significance of histamine in ascaris-induced asthma was confirmed from the present study in which antihistamines were used. A part of airway reactions evoked by histamine are known to occur as the result of the vagal reflex in humans (19)(20)(21), in rabbits (22) and in dogs (23,24) as well as by direct musculotropic action.…”

Section: Discussionmentioning

confidence: 99%

Cardiotonic Action of Ring a-Modified Cardenolides, With Special Reference to Cleavage of the Ring

Yamatake

Sasagawa

Yanaura

et al. 1977

Japanese Journal of Pharmacology

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Abstract-Participationof histamine H1 and H2-receptors in both asthmas, i.e. experimentally induced bronchoconstriction and bronchosecretion, with ascaris suum and histamine in anesthetized dogs was investigated.Dogs given 0.2% histamine solution or ascaris antigen (3 mg protein) by inhalation showed increases in respiratory resistance (Rrs) and respiratory rate to 2.5-5.0 fold. Airway secretion volume was also significantly increased 3-4 fold. The increase in Rrs by histamine inhalation was effectively inhibited or abolished by a histamine HI-receptor antagonist, chlorphenira mine (0.3-1 mg/kg i.v.), but not by a H2-receptor antagonist, cimetidine (1-3 mg/kg i.v.). The increase in Rrs by antigen inhalation was reduced by relatively high doses of chlorpheniramine (1-3 mg/kg i.v.), and not by cimetidine.In contrast, hyperse cretion of tracheobronchial fluid in both asthmas was significantly prevented by either chlorpheniramine or cimetidine. Combinations of both antagonists abolished the hypersecretion.Atropine (2 mg/kg i.v.) significantly inhibited the occurrence of responses in both asthmas. The results suggest that histamine is involved in the allergic asthma produced by ascaris suum and that histamine directly evokes airway constriction through Hl-receptors and hypersecretion of tracheobronchial fluid through H1 and H2-receptors, and, in a part, indirectly activates the cholinergic pathway.There has been much evidence that histamine is the chief chemical mediator released from mast cells during anaphylaxis (1-9).Experimental bronchial asthma in guinea pigs is prominently inhibited by classical antihistamines (10-12). Schild et al. (3) showed un equivocally that histamine release occurs in bronchial tissue of an asthmatic patient.Ash and Schild (13) demonstrated two types of histamine receptors and Black et al.(14) introduced specific antagonists of these receptors which made it possible to characterize and locate these receptors in the body. Data of the presence of H1 and H2-receptors in airway smooth muscle in different species have been documented, and are cited in the review of Chand and Eyre (15). There are, however, specifically no reports on the distribution of these receptors in the dog airway smooth muscle or on the role of these receptors in bron chosecretion. We attempted to characterize histamine receptors responsible for airway constriction and hypersecretion which occurs in ascaris and histamine-induced asthmas, using histamine H1 and H2-receptor antagonists. MATERIALS AND METHODSMale mongrel dogs weighing between 6 and 17 kg were anesthetized with sodium

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“…In general, it is considered that in the mechanisms of airway constrictions pro duced by various chemical mediators, two components (21) are involved, namely, the component (22, 23) mediated by the vagal reflex and caused by the stimulation of three types of peripheral receptors, which may be categorized as the irritant receptors (7,12,14), stretch receptors (14, 24) and C-fiber endings (25) in the airway and the lungs, and the component produced by the direct actions of the chemical mediators on their specific receptors. The effect of Ba598Br pretreatment showed stronger inhibition (70.9%) than vagal blockade.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, it has been reported by Gold et al (7), Yu et al (8) and Yamatake et al (9) that the allergic bron choconstriction is inhibited by atropine or vagal blockade. Furthermore, it has been reported in human beings (10,11) and animals (12)(13)(14) that the vagal reflex is also involved in the airway constriction induced by histamine. These facts suggest that the vagal reflex plays an important role in various airway responses, including asthma.…”

mentioning

confidence: 99%

Effects of 8-(2-fluoroethyl)-3.ALPHA.-hydroxy-1.ALPHA.H, 5.ALPHA.H-tropaniumbromide benzilate (Ba598Br) on allergy- and drug-induced asthmas.

et al. 1983

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Abstract-The effects of Ba598Br , a new atropine derivative possessing a quarternary ammonium salt structure, on the canine airway, including its antiasthmatic effects , were investigated. The in vivo airway resistance was determined using the modified Konzett Rossler method. Inhalation of 0.01 % of Ba598Br had an inhibitory effect against acetyl choline (ACh, 10 Sag/kg i.v.)-evoked bronchoconstriction. The effect of Ba598Br was more powerful and longer lasting than that of the same dose of atropine. Pretreatment with Ba598Br (0.3%) and atropine (0.3%) by inhalation produced a remarkable inhibitory effect on the asthmatic bronchoconstriction induced by inhalation of Ascaris swum antigen in naturally sensitized dogs. In this case, Ba598Br showed a potency of approx. twice that of atropine as estimated from the inhibitory percent. On the other hand, in the case of posttreatment (drugs being inhaled after the antigen inhalation), both drugs showed inhibitory effects of equal degree. As for the effects on increased airway secretion at the time of asthmatic attack, both drugs inhibited the excessive secretions without any remarkable change in the viscosity of the secretions. Inhalation of 0.3% Ba598Br showed a powerful antihistamine action with respect to histamine (Hist, 3 ,tg/kg i.v.) induced bronchoconstriction after the bilateral cervical vagi and superior laryngeal nerves were amputated. However, almost no effect could be observed with the same dose of atropine. Both Ba598Br and atropine showed relaxing actions of the same degree against ACh contraction on the isolated canine trachea, bronchus and bronchiole preparations, with a particularly strong relaxation being observed in the bronchiole. On the other hand, Ba598Br showed relaxing actions against histamine-induced con tractions, which were more powerful than those of atropine, in the bronchus and bronchiole. From the above findings, it is suggested that the Ba598Br inhalation brings about antiasthmatic effects by its persistent, powerful anticholinergic actions and its transient but powerful antihistamine actions.

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New method for perfusing bronchial arteries: histamine bronchoconstriction and apnea.

Cited by 146 publications

References 0 publications

Role of Autonomic Nervous System and the Cough Reflex in the Increased Responsiveness of Airways in Patients with Obstructive Airway Disease*

Role of Autonomic Nervous System and the Cough Reflex in the Increased Responsiveness of Airways in Patients with Obstructive Airway Disease*

Cardiotonic Action of Ring a-Modified Cardenolides, With Special Reference to Cleavage of the Ring

Effects of 8-(2-fluoroethyl)-3.ALPHA.-hydroxy-1.ALPHA.H, 5.ALPHA.H-tropaniumbromide benzilate (Ba598Br) on allergy- and drug-induced asthmas.

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