New method to determine LSER parameters

Abstract

KeyWordsColumn liquid chromatography Micellar liquid chromatography Linear solvation energy relationship Polyaromatic hydrocarbons SummaryNew method was developed to determining ~f l~ and ~r~ descriptors ofthe linear salvation energy relationship (LSER) with micelle water partition coeffident obtained using micellar li quid chromatography (MLC). This method was tested wth chromatographic data of 20 or ganic compounds. Good results obtained confirm the validity of the method that opens new possibilities of predse and reliable determination of LSER descriptors of high boiling corn pounds. This method was used to establish ~/3~ and rr~ descriptors of 23 polyaromatic hy drocarbons that were not avaTlable Tn the literature.

Study of the interaction between glucosamine hydrochloride and sodium dodecylsulphate micelles using conductometric, isothermal calorimetry, zeta-potential titrations, and NMR NOESY

“…28−31 However, the value of K b = 529 is close to those found for drug binding in SDS micelles 32,33 or in liposome systems. 34 Important information can also be obtained by analysis of stoichiometric coefficient N, which suggests a supramolecular structure formed by 0.34 Gl + for each DS − molecule. Considering an average aggregation number of 62 surfactant molecules per micelle of SDS, 35 it was possible to estimate the amount of 21 Gl + molecules required to saturate a micellar solution.…”