Pressure ulcers are a serious health problem for people with mobility disorders, like elders in acute care, longterm care, and home care settings. It also concerns paraplegics, tetraplegics or persons with burned injuries. Pressure ulcers result in significant morbidity and mortality. Consequences are a high human suffering, with high cost in terms of treatment.Several risk factors have been identified for the development of pressure ulcers: they are classified into extrinsic and intrinsic factors. Extrinsic factors include interface pressure, shear forces, friction…Intrinsic factors are the nutritional state of the patient, its age, diseases…There is little information about the mechanism of the formation of pressure sores but it is agreed that it is a complex process. The difficulty of the prevention lies in the evaluation of these factors. It is an essential stage to optimize the preventative measures. Actually, no quantifiable parameters exist to predict the formation of a pressure ulcer.This article is aimed to propose new techniques developed for the early detection of pressure ulcers. First, extrinsic parameters as the interface pressure and its consequences on the mobility are investigated. A new actimeter is presented to monitor the movements of the patient. The second part is dedicated to the presentation of a new imaging technique which can help the physician to control tissue elasticity of the patient. The technique is called elastography, it is a 3D strain estimation of soft biological tissues. Finally, the last way of investigation is the combination of extrinsic and intrinsic factors evaluation for a most relevant earlier diagnosis. Before the description of these techniques, it is essential to understand the phenomenology associated to the development of pressure sores. Only in this way, new techniques can be developed.