New micellar morphologies from amphiphilic block copolymers: disks, toroids and bicontinuous micelles

Holder, Simon J.; Sommerdijk, Nico A. J. M.

doi:10.1039/c0py00379d

Cited by 276 publications

(259 citation statements)

References 104 publications

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“…In recent years there has 3 been increasing interest in the development of new polymeric materials which can undergo selective assembly to form non-spherical morphologies including cylinders, toroids and discs. (23) The application of these non-spherical morphologies has not yet been fully realized, however the potential of cylindrical structures in advanced drug delivery applications has recently been reported. (24) The groups of Endo, Mori and coworkers have pioneered the area of poly(amino acids) over the last 15 years.…”

Section: Introductionmentioning

confidence: 99%

pH-Responsive Chiral Nanostructures

Willcock

Ieong

et al. 2011

Aust. J. Chem.

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There is great current interest in the design of robust synthetic polymers for the preparation of novel functional, well-defined, biocompatible and tailorable materials for a range of applications. In this work we have used reversible addition fragmentation chain transfer (RAFT) polymerization to prepare chiral and responsive amphiphilic block copolymers (based on polyphenylalanine acrylamide) which can be assembled at different pHs to form well-defined nanostructures, whose morphology and size were explored using TEM, DLS and SLS measurements and stability by fluorescence and NMR spectroscopy. 2The application of these chiral and responsive nanostructures in the resolution of hydrophilic racemic amino acids has also been explored.

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Section: Introductionmentioning

confidence: 99%

pH-Responsive Chiral Nanostructures

Willcock

Ieong

et al. 2011

Aust. J. Chem.

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“…[1][2][3][4][5][6] For the TEM analysis of specimens dispersed in liquids, samples are conventionally dried from suspension onto a 30-50 nm carbon or polymer covered metal grid. For organic materials, which are relatively transparent to the electron beam, drying is oen combined with negative staining to generate contrast.…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide single sheets as substrates for high resolution cryoTEM

et al. 2015

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Document VersionPublisher's PDF, also known as Version of Record (includes final page, issue and volume numbers)Please check the document version of this publication:• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Link to publication• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. CryoTEM is an important tool in the analysis of soft matter, where generally defocus conditions are used to enhance the contrast in the images, but this is at the expense of the maximum resolution that can be obtained. Here, we demonstrate the use of graphene oxide single sheets as support for the formation of 10 nm thin films for high resolution cryoTEM imaging, using DNA as an example. With this procedure, the overlap of objects in the vitrified film is avoided. Moreover, in these thin films less background scattering occurs and as a direct result, an increased contrast can be observed in the images. Hence, imaging closer to focus as compared with conventional cryoTEM procedures is achieved, without losing contrast. In addition, we demonstrate an $1.8 fold increase in resolution, which is crucial for accurate size analysis of nanostructures.

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“…[1][2][3][4][5][6] These natural supramolecular structures have inspired scientists to exploit supramolecular self-assembly principles as a tool in order to design and build biomimetic molecular structures from synthetic molecular compounds for purposes such as drug delivery and biomedical diagnostic technologies such as dental, cosmetic surgery, and orthopedic applications. [7][8][9][10][11][12][13][14][15][16] Application of bio-inspired materials requires mass production of their molecular building blocks with efficient methods, which are not necessarily as accurate as the ones employed in research laboratories, or, for that matter, biology.…”

Section: Introductionmentioning

confidence: 99%

Theory of supramolecular co-polymerization in a two-component system

Jabbari-Farouji

Schoot

2012

The Journal of Chemical Physics

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As a first step to understand the role of molecular or chemical polydispersity in self-assembly, we put forward a coarse-grained model that describes the spontaneous formation of quasi-linear polymers in solutions containing two self-assembling species. Our theoretical framework is based on a two-component self-assembled Ising model in which the chemical bidispersity, i.e., the presence of two distinct chemical entities, is parameterized in terms of the strengths of the binding free energies that depend on the monomer species involved in the pairing interaction. Depending upon the relative values of the binding free energies involved, different morphologies of assemblies that include both components are formed, exhibiting random, blocky or alternating ordering of the two components in the assemblies. Analyzing the model for the case of blocky ordering, which is of most practical interest, we find that the transition from conditions of minimal assembly to those characterized by strong polymerization can be described by a critical concentration that depends on the concentration ratio of the two species. Interestingly, the distribution of monomers in the assemblies is different from that in the original distribution, i.e., the ratio of the concentrations of the two components put into the system. The monomers with a smaller binding free energy are more abundant in short assemblies and monomers with a larger binding affinity are more abundant in longer assemblies. Under certain conditions the two components congregate into separate supramolecular polymeric species and in that sense phase separate. We find strong deviations from the expected growth law for supramolecular polymers even for modest amounts of a second component, provided it is chemically sufficiently distinct from the main one.

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New micellar morphologies from amphiphilic block copolymers: disks, toroids and bicontinuous micelles

Cited by 276 publications

References 104 publications

pH-Responsive Chiral Nanostructures

pH-Responsive Chiral Nanostructures

Graphene oxide single sheets as substrates for high resolution cryoTEM

Theory of supramolecular co-polymerization in a two-component system

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