New microfluidic paper-based analytical device for iron determination in urine samples

Ferreira, Francisca T.S.M.; Catalão, Karina A.; Mesquita, Raquel B. R.; Rangel, António O.S.S.

doi:10.1007/s00216-021-03706-9

Cited by 18 publications

(7 citation statements)

References 18 publications

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“…Although the reagents mentioned above were selective, they were synthesized under complicated procedures. The most widely used and commercially available reagents are orthophenanthroline (o-phen) [17,18] and bathophenanthroline (Bphen) [19,20]. Bphen provides higher sensitivity for the iron (II) detection [13].…”

Section: Introductionmentioning

confidence: 99%

“…The complex formation between the iron (II) ion and Bphen ligand, in which a redcolored product is developed, is shown in Figure 1. Some researchers studied the use of Bphen for the analysis of iron by PAD [20], and their work involved simple external calibration assay using PAD for synthetic urine samples. To our knowledge, this work is the first time that a PAD with a two-layer design for the determination of iron in water using the standard addition approach.…”

Section: Introductionmentioning

confidence: 99%

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A Double-layered Paper-based Analytical Device for Determination of Iron in Water Samples based on Standard Addition Method

Srikritsadawong,

Sookpotarom,

Thongchan

et al. 2023

Curr. Appl. Sci. Technol.

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A simple method for the determination of iron involved a novel paper-based analytical device (PAD) was developed. The PAD was composed of two layers. Each layer contained a circular hydrophilic reservoir (10 mm Ø) that was situated in a rectangular filter paper (25 Î 25 mm2). The hydrophobic area was created by painting the paper with a “waterproof” glue. The top and the bottom layers were assigned as “the filtration” and “the detection” platforms, respectively. The procedure was started by pipetting an aliquot of bathophenanthroline (Bphen) onto the hydrophilic zone of the bottom layer followed by spiking of standard solutions (0.1-0.5 mgL-1 Fe2+). The red complex was developed. Then, the top and the bottom layers were assembled by two-sided mounting tape. Later, a water sample was dropped onto the top layer, which removed (filtered) any suspended particles in the water sample. When the filtrate was exposed to the bottom layer, a further colored product formed. The bottom layer was removed and placed in a light-controlled box, and the optical image of the product was captured using a smartphone. Its intensity was evaluated through ImageJTM. Linear standard addition plots were obtained (r2 > 0.99). The PAD provided high precision (RSD < 6%) with good recovery (92.6-102%). It was applied to the analysis of drinking, tap, canal and river water samples without any prior filtration. The iron amounts were compared to the results obtained by the spectrophotometric method, and there was not significantly difference at 95% confidence (Paired-t test, n = 5 samples, tstat = 2.68, tcri = 2.78).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Double-layered Paper-based Analytical Device for Determination of Iron in Water Samples based on Standard Addition Method

Srikritsadawong,

Sookpotarom,

Thongchan

et al. 2023

Curr. Appl. Sci. Technol.

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“…Paper is a widely used material as a chemical platform because it presents the advantage of being available in a range of thicknesses, porosities, and is easy to use, store and transport. As the μPADs are mainly made of paper (and sometimes plastic), they can be disposed by incineration quite quickly and safely [18,19].…”

Section: Introductionmentioning

confidence: 99%

Development of a microfluidic paper-based analytical device for magnesium determination in saliva samples

et al. 2022

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“…Conventional SWASV, on the other hand, suffers from high reagent use, poor reproducibility, and instability [ 18 , 19 ]. Microfluidics, also known as lab-on-a-chip (LOC), has aroused people’s great interest, particularly during the difficult times of the COVID-19 pandemic, for its numerous advantages, such as precise control and manipulation of low-volume fluids, reduced reagent consumption, lowered detection time, higher sensitivity and detection automation [ 20 – 24 ]. Integrated LOC devices, such as centrifugal microfluidics devices, can incorporate many of the necessary functionality of biochemistry and medical analysis field into a tiny chip [ 25 – 27 ].…”

Section: Introductionmentioning

confidence: 99%

Hybrid 3D printed integrated microdevice for the determination of copper ions in human body fluids

Jiang

Zhao

et al. 2022

Anal Bioanal Chem

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On-site screening of copper ions in body fluid plays a critical role in monitoring human health, especially in heavy pollution areas. In this study, we have developed a hybrid 3D printed integrated microdevice for the determination of copper ions in human body fluids. A fixed and low volume of sample was detected by using the integrated microdevice without any preprocessing. The hybrid channel enables sample uniform mixing and quantitative dilution with buffer solution by inducing the “horseshoe vortex” phenomenon. The electrolytic microcell based on the flow detection system shows a more effective copper ion reaction ratio and, as a result, a better sensitivity. The simulation of the finite element method (FEM) determined the relevant optimum parameters of the hybrid channel and the microcell. The design, fabrication, and detection procedure of the integrated microdevice are here illustrated. The microdevice presented superior detection properties towards copper ions. The calibration curves covered two linear ranges varying from 20 to 100 ppb and 100 to 400 ppb, respectively. The limit of detection was estimated to be 15 ppb ( S / N = 3). The relative standard deviation of the peak current measurements was 2.26%. The designed microdevice was further applied to detect copper ions in practical samples (calf serum sample and synthetic human urine sample) using a standard addition method, and the average recovery was found to be 95–104%. The performance of copper ion detection with the integrated microdevice was consistent with that of the inductively coupled plasma mass spectrometry (ICP-MS) in the same practical samples, demonstrating significant practicality in the test of body fluidics. The portable integrated microdevice is an excellent choice for on-site detection and has a promising prospect in the point-of-care testing (POCT) applications. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s00216-022-04049-9.

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New microfluidic paper-based analytical device for iron determination in urine samples

Cited by 18 publications

References 18 publications

A Double-layered Paper-based Analytical Device for Determination of Iron in Water Samples based on Standard Addition Method

A Double-layered Paper-based Analytical Device for Determination of Iron in Water Samples based on Standard Addition Method

Development of a microfluidic paper-based analytical device for magnesium determination in saliva samples

Hybrid 3D printed integrated microdevice for the determination of copper ions in human body fluids

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