New micrometer-sized monodispersed self-assembled amphiphilic polystyrene/poly(n-butyl methacrylate) composite particles of hemispherical morphology: synthesis and characterization

Akiva, Udi; Margel, Shlomo

doi:10.1016/j.colsurfa.2004.10.119

Cited by 16 publications

(6 citation statements)

References 10 publications

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“…Synthetic biodegradable polymers continue to be developed, to allow finer control of biocompatibility, surface properties, drug release and sensitivity to external stimuli. Recently, the ability of synthetic polymers to self-assemble into micro or nanostructures with particular architectures is playing a crucial role in the drug delivery field. , More and more frequently, this characteristic is associated to a change of pH as external stimulus, which acts as a driving force for the polymer self-assembling. − …”

Section: Introductionmentioning

confidence: 99%

“…Recently, the ability of synthetic polymers to self-assemble into micro or nanostructures with particular architectures is playing a crucial role in the drug delivery field. 1,2 More and more frequently, this characteristic is associated to a change of pH as external stimulus, which acts as a driving force for the polymer self-assembling. [3][4][5][6][7] The objective of producing pH-responsive polymer systems could be gained by utilizing polymers with a combination of hydrophobic and charged portions or chains, either as diblock or branched composition.…”

Section: Introductionmentioning

confidence: 99%

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New Self-Assembling Polyaspartamide-Based Brush Copolymers Obtained by Atom Transfer Radical Polymerization

et al. 2009

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A simple and efficient method for the synthesis of polyaspartamide-based brush copolymers using Atom Transfer Radical Polymerization (ATRP) is here presented. The syntheses were performed by using two subsequent steps. In the first step the macroinitiator was obtained by the conjugation of a proper number of 2-bromoisobutyryl bromide (BIB) residues to the R,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) side chains, obtaining the PHEA-BIB copolymer. PHEA-BIB copolymer was used as "multi-functional macroinitiator" for the polymerization via ATRP of hydrophilic methacrylic monomers, such as methacrylic acid (MA), obtaining PHEA-IB-poly(MA) copolymer, sodium methacrylate (MANa + ), obtaining PHEA-IB-poly(MANa + ) copolymer, or hydrophobic monomer such as butyl methacrylate (BMA), obtaining PHEA-IB-poly(BMA) copolymer. BMA was also homopolymerized subsequently MANa + polymerization, extending the poly(MANa + ) chains by poly(BMA) chains arising PHEA-IB-poly(MANa + )-block-poly(BMA) copolymer. Different solvent and temperature conditions were used in order to obtain the best ATRP conditions for each monomer in term of high polymerization efficiency in PHEA side chain. All the synthesized PHEA-based brush copolymers were widely characterized and copolymer self-assembling properties in aqueous media were evaluated by turbidimetry measurements, light scattering and SEM analyses. PHEA-IB-poly(MANa + ) resulted able to form spherical microparticles at pH 2, with a diameter from 1 -5 µm. PHEA-IB-poly(MANa + )-block-poly(BMA) copolymer formed particles at elliptic shape and an internal hollow architecture with an outer diameter of 1-4 µm. Finally, PHEA-IB-poly(BMA) copolymer resulted able to produce microfibers in aqueous medium, with an homogeneous tube shape and a thickness ranging from 3 to 5 µm.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

New Self-Assembling Polyaspartamide-Based Brush Copolymers Obtained by Atom Transfer Radical Polymerization

et al. 2009

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“…There are first reproducible methods to produce so-called Janus particles, i.e. particles with composite surface properties consisting of hydrophobic and hydrophilic regions [37,38]. In contrast to particles with homogeneous surface coating, Janus particles remain strongly attached to the interface even for average contact angles approaching 0 or 180° [39].…”

Section: Interfacial Energy Change By Particle Adsorptionmentioning

confidence: 99%

Composite interfacial layers containing micro-size and nano-size particles

Miller

Fainerman

Kovalchuk

et al. 2006

Advances in Colloid and Interface Science

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“…Both selfassembly of block or graft copolymers [2,3] and template approaches [4] have been proven to be effective ways to obtain polymer-based micelle-like particles. Recently, great efforts have been devoted to developing a block or graft-copolymer-free strategy to fabricate micelles based on polymer pairs.…”

Section: Introductionmentioning

confidence: 99%

Preparation of stable micelle-like particles with rigid backbones based on pyridyl-terminated poly (aryl ether ketone)

Zhang

Liu

Zhang

et al. 2012

Materials Chemistry and Physics

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New micrometer-sized monodispersed self-assembled amphiphilic polystyrene/poly(n-butyl methacrylate) composite particles of hemispherical morphology: synthesis and characterization

Cited by 16 publications

References 10 publications

New Self-Assembling Polyaspartamide-Based Brush Copolymers Obtained by Atom Transfer Radical Polymerization

New Self-Assembling Polyaspartamide-Based Brush Copolymers Obtained by Atom Transfer Radical Polymerization

Composite interfacial layers containing micro-size and nano-size particles

Preparation of stable micelle-like particles with rigid backbones based on pyridyl-terminated poly (aryl ether ketone)

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