New molecules and formulations of recombinant human erythropoietin

Erythropoietins: A common mechanism of action

“…Early attempts to improve rhEPO included enhancing molecular stability or increasing affinity for EPOR [73]. However, increased affinity did not necessarily increase in vivo biological potency, because serum t 1/2 was the primary driver of the degree of response [9,28,74].…”