2024
DOI: 10.33224/rrch.2024.69.1-2.08
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New monoquaternary salts of N-heterocycles: synthesis and antitumor assessment

Monica-Cornelia SARDARU,
Cristina-Maria AL MATARNEH,
Natalia SIMIONESCU
et al.

Abstract: This manuscript presents the synthesis, structural characterization, and antitumor evaluation of new monoquaternary salts derived from various N-heterocycles. For quinoline and quinoxaline, respectively, unexpected H-bonded mixtures of the reactants have been obtained. To assess their potential antitumor activity, the comprehensive panel of NCI's 60 human cancer cell lines was employed. Remarkably, mixtures 3g and 3h displayed significant inhibitory activity against leukemia, melanoma, and colon cancer cell li… Show more

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