New Monoterpene Glycosides from Paeonia emodi

Muhammad, Pir; Ahmad, Saeed; Rubnawaz, Hafiz; Ullah, Nisar; Malik, Abdul

doi:10.1515/znb-1999-0419

Cited by 13 publications

(9 citation statements)

References 2 publications

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“…Paeonia emodi Royle (Paeoniaceae) is an erect glabrous, leafy perennial herb indigenous to north-west Himalayas from Kashmir to Kumaon commonly known as Oodsaleeb [ 5 , 6 ]. Several phytochemical studies have revealed that the root contains monoterpene glycosides [ 7 ], monoterpene galactosides (paeonin A, B, and C) [ 8 ], triterpene (emodinol) [ 9 ], 1,5-dihydroxy-3-methyl-anthraquinone, ethyl gallate, and methyl grevillate [ 10 ]. Various component of plant root showed β-glucouronidase inhibitory activity [ 10 ], lipoxygenase inhibiting activity, hydroxyl radical scavenging activity, neuroprotection [ 11 ], and anticonvulsant activities [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Nephroprotective effect of Paeonia emodi via inhibition of advanced glycation end products and oxidative stress in streptozotocin–nicotinamide induced diabetic nephropathy

Kishore¹,

Kaur²,

Singh³

2017

Journal of Food and Drug Analysis

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The present study aimed to evaluate the effect of alcohol (PA) and hydroalcohol (PHA) extract of Paeonia emodi Royale roots in treatment of streptozotocin-nicotinamide induced diabetic nephropathy. Diabetes mellitus was induced in male Wistar rats by streptozotocin (65 mg/kg intraperitoneally) 15 minutes after nicotinamide (230 mg/kg, intraperitoneally) administration and diabetic nephropathy was assessed by measuring serum glucose, renal parameters (urea, uric acid, creatinine, and blood urea nitrogen level) and lipid profile. The rats were treated with different doses of extracts (100 mg/kg, 200 mg/kg, and 400 mg/kg) for 45 days. Oxidative stress was assessed by measuring tissue antioxidant enzymes level along with the formation of advanced glycation end-products (AGEs) in kidney. PA and PHA (400 mg/kg) produced significant attenuation in the serum glucose level (165.08 ± 3.353 mg/dL and 154.27 ± 2.209 mg/dL, respectively) as compared to control. Elevated renal parameters, lipid levels, tissue antioxidant enzymes and AGE formation were also restored in a dose-dependent manner. These findings suggest that by amelioration of oxidative stress and formation of AGEs, PA and PHA significantly inhibited the progression diabetic nephropathy in rats.

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Section: Introductionmentioning

confidence: 99%

Nephroprotective effect of Paeonia emodi via inhibition of advanced glycation end products and oxidative stress in streptozotocin–nicotinamide induced diabetic nephropathy

Kishore¹,

Kaur²,

Singh³

2017

Journal of Food and Drug Analysis

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“…ISSN 2157-6076 2018 Various valuable compounds have been isolated from this plant including oleanolic acid, ethyl gallate, methyl Greville, betulinic acid and 1, 5-dihydroxy-3-methylanthraquinone (Nawaz et al, 2000). Other constituents extracted from this plant are; monoterpene glycosides, wording, and benzoylwurdin along with lactoferrin, paeoniflorin, and oxy-paeoniflorin (Muhammad et al, 1999). Emodinol is an important constituent of this plant which is an oleane type triterpene, having substantial glucuronidase inhibitory action.…”

Section: Journal Of Biology and Life Sciencementioning

confidence: 99%

Hepatoprotective Effects of Various Solvent Extracted Samples of Paeonia Emodi (wall) in Mice with Paracetamol-Induced Hepatotoxicity

Zeb¹,

Shafiq²,

Khan³

et al. 2018

JBLS

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The goal of present study is to evaluate and recognize the most effective hepatoprotective solvent fractions of methanolic extract of Paeonia emodi by fractionating and assessing its fractions for hepatoprotective effect in paracetamol-induced liver damage in mice. In this study, some liver-related serum parameters such as AST, ALP, and ALT were studied. Maximum reduction was caused by aqueous extract (61.08 %) followed by a butanol extract (60.26 %), chloroform extract (48.76 %), crude extract (45.48 %) and drug (37.93 %), in case of ALT. During the study of AST, chloroform extract caused a maximum reduction (65.94 %), followed by a butanol extract (60.43 %), aqueous extract (57.13 %), crude extract (57.13 %) and drug (43.94 %). During the study of ALP aqueous fraction caused a maximum reduction (47.22 %), followed by a butanol fraction (44.44 %), chloroform (41.51 %), methanol extract (34.72 %) and drug (20.83 %). In all the treatment groups the serum levels of ALT, AST and ALP were significantly lower as compared to those of untreated controlled group (P<0.05). The present research showed that Paeonia emodi has the potential to reduce paracetamol-induced hepatotoxicity in mice and restore the normal liver function.

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“…Previously monoterpene glycosides have been reported from the roots of Paeonia emodi Wall. ex Royle [ 7 , 8 ]. Oleanolic acid, betulinic, ethyl gallate, methyl grevillate, and 1,5-dihydroxy-3-methylanthraquinone are some of the components extracted from this plant.…”

Section: Introductionmentioning

confidence: 99%

“…[ 9 ]. Different constituents are monoterpene glycosides, wurdin and 15 benzoyl wurdin alongside paeoniflorin, lactiflorin and oxypaeoniflorin [ 7 ]. The different other constituents extracted from this plant incorporate a β-glucuronidase-repressing triterpene, Pa 11,beta,5alpha,23,24-pentahydroxy-30-norolean-12,20(29)-d ien-28-oic acid, oleanolic acid, betulinic acid, ethyl gallate, methyl grevillate and 1,5-dihydroxy-3-methylanthraquinone [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives

et al. 2023

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Paeoniaemodi Wall. ex Royle is commonly known as Himalayan paeony has great importance as a food and medicine. The practice of Paeoniaemodi Wall. ex Royle is very ancient and it is conventionally used for a wide range of illnesses in the folk system of medicine because of its wide beneficial phytochemical profile. The main purpose of the current review was the synthesis of recent data on botany, ethnopharmacology, phytochemistry and potential pharmacological mechanisms of action of Paeoniaemodi Wall. ex Royle, thus offering new prospects for the development of new adjuvant natural therapies. Using scientific databases such as PubMed/MedLine, Scopus, Web of Science, ScienceDirect, Google Scholar, Springer, and Wiley, a comprehensive literature search was performed for Paeoniaemodi Wall. ex Royle. For searching, we used the next MeSH terms: “Biological Product/isolation and purification”, “Biological Products/pharmacology”, “Drug Discovery/methods”, “Ethnopharmacology, Medicine”, “Traditional/methods”, “Paeonia/chemistry”, “Plant Extracts/pharmacology”, “Phytochemicals/chemistry”, “Phytochemicals/pharmacology”, “Plants, Medicinal”. The results of the most recent studies were analyzed and the most important data were summarized in tables and figures. Phytochemical research of Paeoniaemodi Wall. ex Royle has led to the isolation of triterpenes, monoterpenes, phenolic acids, fatty acids, organic compounds, steroids, free radicals and some other classes of primary metabolites. In addition, diverse pharmacological activities like antibacterial, antifungal, anticoagulant, airway relaxant lipoxygenase and beta-glucuronidase inhibiting activity, radical scavenging activity, phytotoxic and insecticidal activities have been reported for Paeoniaemodi Wall. ex Royle. Different bioactive compounds of Paeoniaemodi Wall. ex Royle has proven their therapeutic potential in modern pharmacological and biomedical research to cure numerous gastrointestinal and nervous disorders. In future, further in vitro and in vivo therapeutic studies are required to identify new mechanisms of action, pharmacokinetics studies, and new pharmaceutical formulations for target transport and possible interaction with allopathic drugs. Also, new research regarding quality evaluation, toxicity and safety data in humans is needed.

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New Monoterpene Glycosides from Paeonia emodi

Cited by 13 publications

References 2 publications

Nephroprotective effect of Paeonia emodi via inhibition of advanced glycation end products and oxidative stress in streptozotocin–nicotinamide induced diabetic nephropathy

Nephroprotective effect of Paeonia emodi via inhibition of advanced glycation end products and oxidative stress in streptozotocin–nicotinamide induced diabetic nephropathy

Hepatoprotective Effects of Various Solvent Extracted Samples of Paeonia Emodi (wall) in Mice with Paracetamol-Induced Hepatotoxicity

A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives

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