This article presents an overview of published studies on interventions with children and adolescents living with a parent who has a chronic somatic illness, organized according to type of intervention, children's age, stage of parental illness, and the goals, techniques, theoretical basis, duration, evaluation, and outcome of the intervention. Issues concerning children's psychological response to parental illness are addressed. Useful clinical guidelines are presented, including the promotion of illness-related knowledge and coping skills in children and the selection of treatment goals and intervention techniques according to the child's developmental needs, the family needs, and the stage of parental illness. The need for interventions for very young children and for evidence-based intervention studies is discussed.Keywords: child and family intervention, children of parents with illness, group intervention, child psychotherapy 1 This review used articles and books retrieved from various sources, including the MEDLINE, PsycINFO, and CANCERLIT databases for the years 1984 to 2004. In the database search, the terms children and family were combined with ill parents, disabled parents, intervention, chronic disease, and several illness names, such as cancer and multiple sclerosis.