New multicomponent reactions in water: a facile synthesis of 1,3-dioxo-2-indanilidene-heterocyclic scaffolds and indenoquinoxalines through reaction of ninhydrin-malononitrile adduct with diverse N-binucleophiles

Abstract

A one-pot three-component synthesis of indenoquinoxalines and various exocyclic enaminones, imidazolidin-2-ylidene-indenedione, pyrimidine-2-ylidene-indenedione, in water.

Advanced Guareschi–Thorpe synthesis of pyridines in green buffer, and pH-controlled aqueous medium with ammonium carbonate

“…27 Additionally, a series of water-based organic reactions accelerated by microwave [28][29][30] or ultrasound irradiation 31 occurred within minute scale times instead of days. Combination of the water-based organic synthesis 32 with the multi-component reactions 33,34 provided water-based MCRs 35 as a highlight division of green chemistry to produce the complex bioorganic molecules. Typically, water-based MCRs have developed as recent post-methods for the synthesis of various heterocyclic compounds.…”