This paper is concerned with the existence and multiplicity of monotone positive solutions for a class of nonlinear fractional differential equation with a disturbance parameter in the integral boundary conditions on the infinite interval. By using Guo–Krasnosel’skii fixed-point theorem and the analytic technique, we divide the range of parameter for the existence of at least two, one and no positive solutions for the problem. In the end, an example is given to illustrate our main results.