2022
DOI: 10.1016/j.snb.2022.131661
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New nanostructures inhibiting human mannose binding lectin identified by a novel surface plasmon resonance assay

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(2 citation statements)
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“…For high-affinity MBL recognition and binding, we developed so-called Man-EG 6 C 11 S-coated GNRs, consisting of monovalent mannose coupled onto the GNR surfaces using an amphiphilic linker (EG 6 C 11 –SH) containing six units of ethylene glycol. Similarly Man-EG 6 C 11 S-coated gold nanospheres have recently shown promising results as MBL inhibitors using an SPR-based assay . The highly flexible chain of polyethylene glycol (PEG) can adopt a wide variety of conformations making undesired interactions with proteins or other blood components under physiological conditions thermodynamically unfavorable .…”
Section: Introductionmentioning
confidence: 99%
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“…For high-affinity MBL recognition and binding, we developed so-called Man-EG 6 C 11 S-coated GNRs, consisting of monovalent mannose coupled onto the GNR surfaces using an amphiphilic linker (EG 6 C 11 –SH) containing six units of ethylene glycol. Similarly Man-EG 6 C 11 S-coated gold nanospheres have recently shown promising results as MBL inhibitors using an SPR-based assay . The highly flexible chain of polyethylene glycol (PEG) can adopt a wide variety of conformations making undesired interactions with proteins or other blood components under physiological conditions thermodynamically unfavorable .…”
Section: Introductionmentioning
confidence: 99%
“…Similarly Man-EG 6 C 11 S-coated gold nanospheres have recently shown promising results as MBL inhibitors using an SPR-based assay. 31 The highly flexible chain of polyethylene glycol (PEG) can adopt a wide variety of conformations making undesired interactions with proteins or other blood components under physiological conditions thermodynamically unfavorable. 32 Moreover, due to the hydrophilic nature of the ethylene glycol chain, it generates a hydrated cloud leading to a low attraction of surrounding proteins.…”
Section: Introductionmentioning
confidence: 99%