New nitrosyl ruthenium complexes with combined activities for multiple cardiovascular disorders

Gouveia, Florêncio S.; Silveira, João Alison Moraes; Holanda, Thais Muratori; Ridnour, Lisa A.; Wink, David A.; Siqueira, Rodrigo José Bezerra; Monteiro, Helena Serra Azul; Sousa, Eduardo Henrique Silva; Lopes, Luiz Gonzaga de França

doi:10.1039/d3dt00059a

Cited by 8 publications

(1 citation statement)

References 97 publications

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“…It is well recognised that there are difficulties in finding a consistent description of the bonding in metal nitrosyl complexes using simple models, and this has led to much discussion over several decades. Moreover, although this debate has generally been a topic primarily of academic interest, the potential applications of metal nitrosyls, including in medicine, have recently attracted considerable attention [58,59].…”

Section: Cationic Ligands: Linear No and Tropyliummentioning

confidence: 99%

The dn Number in Transition Metal Chemistry: Its Utility and Limitations

Norman,

Pringle

2023

Chemistry

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The dn number or configuration is a very useful parameter in transition metal chemistry because it conveys information about the expected properties of a d-block metal complex, including its shape, magnetism, thermodynamic stability, kinetic lability, and spectroscopic properties. The dn number can be determined from either the oxidation state (OS) or valence number (VN) of the metal centre, and since, in most cases, these are numerically equal, the derived dn value is the same. However, examples are discussed where the OS and VN are not equal, which results in unavoidable ambiguities in dn values. Following a discussion of these examples, a revised definition of dn is proposed based on the occupation of the frontier molecular orbitals of the complex.

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Section: Cationic Ligands: Linear No and Tropyliummentioning

confidence: 99%

The dn Number in Transition Metal Chemistry: Its Utility and Limitations

Norman,

Pringle

2023

Chemistry

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Novel Ruthenium‐based Nitrosyl Complexes: NO Donation and Vasorelaxant Potentials for Cardiovascular Therapeutics

Gouveia Júnior,

de Sousa,

da Silva

et al. 2024

Eur J Inorg Chem

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Nitrosyl ruthenium complexes have emerged as promising platforms for the controlled delivery of nitric oxide (NO) and nitroxyl (HNO), both of which possess significant therapeutic implications. Considering this scenario, we synthesized and characterized the metal complex cis‐[RuNO(phen)2(2MIM)]3+ and its precursors, where phen and 2MIM correspond to 1,10‐phenantroline and 2‐methylimidazole, respectively. Comprehensive structural elucidation was undertaken using a combination of spectroscopic and electrochemical methodologies, including XANES/EXAFS experiments. This structural data was further validated through DFT computational analyses. We demonstrated that such compound can release NO and HNO in the presence of thiol‐based substrates. Not only this, but the same metal complex can also delivery nitric oxide under irradiation with visible light (λ=460 nm). The nitrosyl complex and its derivatives displayed marked vasodilatory capabilities as evidenced in assays involving isolated rat aorta rings. They also exhibited commendable antioxidant activity in free radical scavenging assays. Collectively, based on these data, this nitrosyl ruthenium compound is a potential therapeutic candidate, especially in the field of cardiovascular pathology like atherosclerosis, thereby deserving further in‐depth investigations.

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Visible light induced generation of nitric oxide from designed ruthenium nitrosyl complex and studies on antibacterial activity

Singh,

Chaudhary,

Prasad

et al. 2024

Journal of Molecular Structure

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New nitrosyl ruthenium complexes with combined activities for multiple cardiovascular disorders

Abstract: Nitrosyl ruthenium complexes are promising platforms for nitric oxide (NO) and nitroxyl (HNO) release, which exert their therapeutic application. In this context, we developed two polypyridinic compounds with general formula...

Cited by 8 publications

References 97 publications

The dn Number in Transition Metal Chemistry: Its Utility and Limitations

The dn Number in Transition Metal Chemistry: Its Utility and Limitations

Novel Ruthenium‐based Nitrosyl Complexes: NO Donation and Vasorelaxant Potentials for Cardiovascular Therapeutics

Visible light induced generation of nitric oxide from designed ruthenium nitrosyl complex and studies on antibacterial activity

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