New NO‐Donors with Antithrombotic and Vasodilating Activities, Part 15 Nitrolic Acids

Rehse, Klaus; Herpel, Martin; Piechocki, D

doi:10.1002/ardp.19963290205

Cited by 23 publications

(26 citation statements)

References 8 publications

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“…Thereby the application volume was kept constant to 0.1 mL/100 g body weight. The thrombosis experiments [6] and the b.p. measurements [7] were carried out as already described.…”

Section: Experimental Partmentioning

confidence: 99%

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Interaction of Viagra with the NO Donors Molsidomine and RE 2047 with Regard to Antithrombotic and Blood Pressure Lowering Activities

Rehse¹,

Scheffler

Reitner

1999

Arch. Pharm. Pharm. Med. Chem.

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After p.o. administration to rats in doses up to 30 mg/kg, Viagra showed no antithrombotic effect. However, it enhanced the inhibition of thrombus formation by RE 2047 from 9% to 17% (5 + 5 mg/kg) or 19% to 27% (10 + 10 mg/kg) in arterioles. This effect was even more obvious in venules where an inhibition of 9% (5 + 5 mg/kg) or 15% (10 + 10 mg/kg) was seen whereas the individual drugs had no effect. The antithrombotic activity of molsidomine was not altered. The blood presssure (b.p.) of spontaneously hypertensive rats was reduced by the combination of Viagra and RE 2047 (5 + 5 mg/kg) to 94% of normal after 2 h while the individual drugs had no effect at this dose. The coadminstration of 10 mg/kg of each drug reduced the b.p. to 87% of normal. The combination of Viagra with molsidomine decreased b.p. to 84% (5 + 5 mg/kg) or 79% (10 + 10 mg/kg), respectively.

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“…Thereby the application volume was kept constant to 0.1 mL/100 g body weight. The thrombosis experiments [6] and the b.p. measurements [7] were carried out as already described.…”

Section: Experimental Partmentioning

confidence: 99%

“…The antithrombotic effects of the single drugs and their combinations were assayed in a laser thrombosis model [6] . The compounds were administered orally to rats.…”

Section: Antithrombotic Effectsmentioning

confidence: 99%

Interaction of Viagra with the NO Donors Molsidomine and RE 2047 with Regard to Antithrombotic and Blood Pressure Lowering Activities

Rehse¹,

Scheffler

Reitner

1999

Arch. Pharm. Pharm. Med. Chem.

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“…Among the NO-NSAIDs that have come into clinical trials are nitroaspirin, nitronaproxene, nitroketoprofen, etc. Among the nitric oxide donors adopted to prove the validity of this principle are furoxanes, oximes, hydrazides, and organic nitrates [13][14][15] . However, the long-term safety profile of such emerging classes of compounds is still to be determined.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, and evaluation of anti-inflammatory, analgesic, ulcerogenicity, and nitric oxide releasing studies of novel indomethacin analogs as non-ulcerogenic derivatives

Bhandari¹,

Parikh²,

Bothara³

et al. 2010

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Among the nitric oxide donors adopted to prove the validity of this principle are furoxans, oximes, hydrazides, and organic nitrates. (Mann, 2003;Keeble and Moore, 2002;Rehse and Brehme, 2000).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of anti-inflammatory, analgesic, ulcerogenicity and nitric oxide-releasing studies of novel ibuprofen analogs as nonulcerogenic derivatives

Sarkate¹,

Lokwani²,

Patil³

et al. 2010

Med Chem Res

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Since the last 41 years, Ibuprofen has been one of the most widely used Non-Steroidal Anti-Inflammatory Drug (NSAID) due to its anti-inflammatory actions. As all the NSAIDs are suffering from the deadlier GI toxicities, Ibuprofen also is no exception to these toxicities. The free -COOH group is thought to be responsible for the Gastrointestinal (GI) tract toxicity associated with all the traditional NSAIDs. Therefore, the main aim of this study was to develop new chemical entities as potential anti-inflammatory agents with less GI toxicities. In this article, synthesis of a series of Hybrid molecules containing important pharmacophore of Ibuprofen and substituted diaryl rings on 5-membered heterocycle similar to coxibs and Nitric oxidereleasing moiety are described. All the synthesized compounds were tested in vivo for their anti-inflammatory, analgesic, ulcerogenic properties, and histopathological studies and in vitro for their nitric oxide-releasing properties. Out of the six synthesized compounds, four compounds showed significant anti-inflammatory and analgesic activity which was compared with standard. All the synthesized compounds exhibited significant nitric oxide-releasing and reduced GI ulcerogenic activity.

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New NO‐Donors with Antithrombotic and Vasodilating Activities, Part 15 Nitrolic Acids

Cited by 23 publications

References 8 publications

Interaction of Viagra with the NO Donors Molsidomine and RE 2047 with Regard to Antithrombotic and Blood Pressure Lowering Activities

Interaction of Viagra with the NO Donors Molsidomine and RE 2047 with Regard to Antithrombotic and Blood Pressure Lowering Activities

Design, synthesis, and evaluation of anti-inflammatory, analgesic, ulcerogenicity, and nitric oxide releasing studies of novel indomethacin analogs as non-ulcerogenic derivatives

Synthesis and evaluation of anti-inflammatory, analgesic, ulcerogenicity and nitric oxide-releasing studies of novel ibuprofen analogs as nonulcerogenic derivatives

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