New Non-invasive Techniques to Quantify Skin Surface Strain and Sub-surface Layer Deformation of Finger-pad during Sliding

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

“…However, how mechanical stress is dissipated within the nucleus, and how chromatin responds to and is protected against mechanical stress, are less known. To identify such mechanisms and properties, we exposed EPC monolayers to increasing amplitudes of physiologically relevant cyclic, uniaxial mechanical stretch (Liu et al, 2017;Wessendorf and Newman, 2012). We observed that stretch triggers immediate nuclear deformation that leads to Piezo1-mediated calcium release from the ER to reduce laminaassociated H3K9me3 heterochromatin and subsequent nuclear softening.…”

A new device for the combined measurement of friction and through-thickness deformation on ex vivo skin samples

“…The coefficient of friction alone does not allow to fully describe the mechanics involved in skin interaction with objects, as it integrates various local phenomena that are not generally uniform over the apparent area of contact. For example, using an optical method called digital image correlation (DIC), Liu et al [30] showed that upon sliding contact with glass, the strains were not evenly distributed over the fingerpad. Despite OCT imaging of the skin epidermis while sliding, only a limited structural analysis in skin depth was possible.…”

Morphology of a human finger pad during sliding against a grooved plate: A pilot study

“…Optical Coherence Tomography (OCT) has recently been used to study finger-pad skin surface and sub-surface strain during sliding [7], sub-clinical assessment using angiography to assess severity of skin suffering with atopic dermatitis [8], changes on eye/eye-lid surface during contact lens interaction [9] and morphological parameters changes of forearm skin during natural stretching [10]. As such, the aim of this study was to investigate the feasibility of using an OCT system to capture the morphological changes of finger pad ridges across a counterface material with an uneven surface.…”