2015
DOI: 10.1210/jc.2015-2079
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New Nordic Diet–Induced Weight Loss Is Accompanied by Changes in Metabolism and AMPK Signaling in Adipose Tissue

Abstract: NND-induced metabolic improvements were accompanied by increased AMPK signaling in SCAT, suggesting a role of AMPK in these adaptations. The concomitant up-regulation of key glucose and lipid-handling proteins suggests an improved metabolic capacity in adipose tissue after weight loss.

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Cited by 44 publications
(37 citation statements)
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“…Furthermore, reduced AMPK activity has been reported in adipose tissue of insulin resistant volunteers compared with BMI-matched insulin sensitive controls (Gauthier et al., 2011) and weight loss is associated with increased adipose tissue AMPK activity and insulin sensitivity (Fritzen et al., 2015, Xu et al., 2015), although SCAT TNF-α and IL-1β mRNA levels were unchanged after weight loss (Xu et al., 2015). Multiple lines of evidence suggest activation of AMPK is a useful therapeutic aim in obesity and insulin resistance.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, reduced AMPK activity has been reported in adipose tissue of insulin resistant volunteers compared with BMI-matched insulin sensitive controls (Gauthier et al., 2011) and weight loss is associated with increased adipose tissue AMPK activity and insulin sensitivity (Fritzen et al., 2015, Xu et al., 2015), although SCAT TNF-α and IL-1β mRNA levels were unchanged after weight loss (Xu et al., 2015). Multiple lines of evidence suggest activation of AMPK is a useful therapeutic aim in obesity and insulin resistance.…”
Section: Discussionmentioning
confidence: 99%
“…Samples of subcutaneous adipose tissue were homogenized (Tissue Lyzer II, Qiagen, Germany) in ice-cold buffer as described previously [28]. Homogenates were rotated end-over-end for one hour, and lysate supernatants were collected by centrifuging 20 min at 16,000 g at 4 °C.…”
Section: Methodsmentioning
confidence: 99%
“…Secondly, in moderately obese adults, chronic exercise reduces inflammatory markers (i.e. TNF‐α, IL‐6) and leptin in mesenteric AT (Jung et al ., ; Fritzen et al ., ). Thirdly, even after a single bout of swimming, exercise was shown to improve insulin action and inflammation in the stromal vascular fraction (SVF) of AT (Oliveira et al ., ), which are the connective tissue cells of AT.…”
Section: Introductionmentioning
confidence: 97%