New Oleic Acid‐Capped Mesoporous Silica Particles as Surfactant‐Responsive Delivery Systems

Poyatos‐Racionero, Elisa; Pérez‐Esteve, Édgar; Marcos, M. Dolores; Baviera, José Manuel Barat; Martínez‐Máñez, Ramón; Aznar, Elena; Bernardos, Andrea

doi:10.1002/open.201900092

Cited by 8 publications

(10 citation statements)

References 34 publications

(60 reference statements)

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“…In these systems, the gated materials can ideally show a “zero” payload release, yet the presence of predefined physical, chemical or biochemical stimuli induce pore opening and cargo delivery. This concept has been widely applied to drug delivery [ 26 , 27 ], sensing [ 28 , 29 ] and communication protocols [ 30 , 31 , 32 ]. Among gating moieties, proteins have been employed as pore-blocking agents in hybrid MSP materials, allowing entrapped cargo release when proteolytic enzymes are present [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Towards the Enhancement of Essential Oil Components’ Antimicrobial Activity Using New Zein Protein-Gated Mesoporous Silica Microdevices

Poyatos‐Racionero

Guarí-Borràs

Ruiz-Rico

et al. 2021

IJMS

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The development of new food preservatives is essential to prevent foodborne outbreaks or food spoilage due to microbial growth, enzymatic activity or oxidation. Furthermore, new compounds that substitute the commonly used synthetic food preservatives are needed to stifle the rising problem of microbial resistance. In this scenario, we report herein, as far as we know, for the first time the use of the zein protein as a gating moiety and its application for the controlled release of essential oil components (EOCs). The design of microdevices consist of mesoporous silica particles loaded with essential oils components (thymol, carvacrol and cinnamaldehyde) and functionalized with the zein (prolamin) protein found in corn as a molecular gate. The zein protein grafted on the synthesized microdevices is degraded by the proteolytic action of bacterial enzymatic secretions with the consequent release of the loaded essential oil components efficiently inhibiting bacterial growth. The results allow us to conclude that the new microdevice presented here loaded with the essential oil component cinnamaldehyde improved the antimicrobial properties of the free compound by decreasing volatility and increasing local concentration.

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Section: Introductionmentioning

confidence: 99%

Towards the Enhancement of Essential Oil Components’ Antimicrobial Activity Using New Zein Protein-Gated Mesoporous Silica Microdevices

Poyatos‐Racionero

Guarí-Borràs

Ruiz-Rico

et al. 2021

IJMS

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“…Among these stimuli, differences in pH values or redox potential can be highlighted, as well as specific enzymes secreted by the GIT tissues and their sheltered microbiota [ 34 ]. In fact, different MSPs have been used to effectively reach the GIT and deliver their cargo through pH-, redox- or enzyme-responsive molecular gates [ 16 , 23 , 35 , 36 , 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Lactose-Gated Mesoporous Silica Particles for Intestinal Controlled Delivery of Essential Oil Components: An In Vitro and In Vivo Study

et al. 2021

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Mesoporous silica microparticles functionalized with lactose for the specific release of essential oil components (EOCs) in the small intestine are presented. In vitro and in vivo intestinal models were applied to validate the microparticles (M41-EOC-L), in which the presence of lactase acts as the triggering stimulus for the controlled release of EOCs. Among the different microdevices prepared (containing thymol, eugenol and cinnamaldehyde), the one loaded with cinnamaldehyde showed the most significant Caco-2 cell viability reduction. On the other hand, interaction of the particles with enterocyte-like monolayers showed a reduction of EOCs permeability when protected into the designed microdevices. Then, a microdevice loaded with cinnamaldehyde was applied in the in vivo model of Wistar rat. The results showed a reduction in cinnamaldehyde plasma levels and an increase in its concentration in the lumen of the gastrointestinal tract (GIT). The absence of payload release in the stomach, the progressive release throughout the intestine and the prolonged stay of the payload in the GIT-lumen increased the bioavailability of the encapsulated compound at the site of the desired action. These innovative results, based on the specific intestinal controlled delivery, suggest that the M41-payload-L could be a potential hybrid microdevice for the protection and administration of bioactive molecules in the small intestine and colon.

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“…In this work, the cargo release mode of the different microdevices was evaluated in the presence of bile salts, which act as emulsifiers. The action mechanism of OA as a molecular gate was described in previous works of the group [ 46 ]. The interaction forces between the hydrophobic tails of the lipid molecules anchored to the MSPs surface act as closing forces, which avoid cargo release from the system to an aqueous environment.…”

Section: Resultsmentioning

confidence: 99%

“…Solids were synthesized following the procedure described in previous works of the group with slight modifications [ 46 ]. In a typical synthesis, 500 mg of the initial materials (M41, M48, S15 or U7) were suspended in 15 mL of an aqueous solution of RhB (192 mg, 0.4 mol) and stirred during 24 h to obtain the loaded solids (M41-RhB, M48-RhB, S15-RhB and U7-RhB, respectively), which were centrifuged and dried under vacuum.…”

Section: Methodsmentioning

confidence: 99%

“…Oleic acid (OA) has been demonstrated to be a good gating entity when functionalized onto MSPs for cargo delivery in the small intestine, avoiding cargo release when no bile salts (or surfactants) are present [ 46 ]. Its good behavior in both open and closed state was the reason why it was chosen as model to act as the molecular gate for the different mesoporous systems under this study.…”

Section: Introductionmentioning

confidence: 99%

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Surfactant-Triggered Molecular Gate Tested on Different Mesoporous Silica Supports for Gastrointestinal Controlled Delivery

Poyatos‐Racionero

González‐Álvarez

et al. 2020

Nanomaterials

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In recent decades, the versatility of mesoporous silica particles and their relevance to develop controlled release systems have been demonstrated. Within them, gated materials able to modulate payload delivery represent great advantages. However, the role played by the porous matrix in this kind of systems is scarce. In this work, different mesoporous silica materials (MCM-41, MCM-48, SBA-15 and UVM-7) are functionalized with oleic acid as a molecular gate. All systems are fully characterized and their ability to confine the entrapped cargo and release it in the presence of bile salts is validated with release assays and in vitro digestion experiments. The cargo release profile of each synthesized support is studied, paying attention to the inorganic scaffold. Obtained release profiles fit to Korsmeyer–Peppas model, which explains the differences among the studied supports. Based on the results, UVM-7 material was the most appropriate system for duodenal delivery and was tested in an in vivo model of the Wistar rat. Payload confinement and its complete release after gastric emptying is achieved, establishing the possible use of mesoporous silica particles as protection and direct release agents into the duodenum and, hence, demonstrating that these systems could serve as an alternative to the administration methods employed until now.

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New Oleic Acid‐Capped Mesoporous Silica Particles as Surfactant‐Responsive Delivery Systems

Cited by 8 publications

References 34 publications

Towards the Enhancement of Essential Oil Components’ Antimicrobial Activity Using New Zein Protein-Gated Mesoporous Silica Microdevices

Towards the Enhancement of Essential Oil Components’ Antimicrobial Activity Using New Zein Protein-Gated Mesoporous Silica Microdevices

Lactose-Gated Mesoporous Silica Particles for Intestinal Controlled Delivery of Essential Oil Components: An In Vitro and In Vivo Study

Surfactant-Triggered Molecular Gate Tested on Different Mesoporous Silica Supports for Gastrointestinal Controlled Delivery

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