2023
DOI: 10.1002/jmv.28946
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New‐onset and relapsed thrombotic microangiopathy post‐COVID‐19 vaccination

Abstract: Thrombotic microangiopathy (TMA) associated with coronavirus disease 2019 (COVID-19) vaccination has been reported, however, the clinical characteristics and pathogenesis remained mysterious. We reviewed 84 TMA cases post-COVID-19 vaccination, including 64 patients diagnosed with thrombotic thrombocytopenic purpura (TTP), 17 cases presented as atypical hemolytic uremic syndrome (aHUS), and three cases manifested as unclassified TMA. TMA episodes were mostly associated with messenger RNA vaccines. For TTP, 67.6… Show more

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Cited by 3 publications
(2 citation statements)
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“…The presented case shows similarity with the results for Ma Q and Xu G review, 3 being more incident in women, after the first dose of immunization without renal alteration previously. However, it contrasts by presenting itself in a patient of age below the average age of the cases reported, in addition to having been caused after the application of an adenoviral vector vaccine (as shown in another study), 10 starting symptoms after 15 days of the administration and not showing complete remission of the case and still requiring hemodialysis.…”
Section: Discussionsupporting
confidence: 85%
See 1 more Smart Citation
“…The presented case shows similarity with the results for Ma Q and Xu G review, 3 being more incident in women, after the first dose of immunization without renal alteration previously. However, it contrasts by presenting itself in a patient of age below the average age of the cases reported, in addition to having been caused after the application of an adenoviral vector vaccine (as shown in another study), 10 starting symptoms after 15 days of the administration and not showing complete remission of the case and still requiring hemodialysis.…”
Section: Discussionsupporting
confidence: 85%
“…2 A recent review of 84 new-onset or relapsed thrombotic microangiopathy (TMA) cases post-COVID-19 vaccination showed a strong association with messenger RNA vaccines. 3 TMA refers to a group of syndromes characterized by microvascular hemolytic anemia and thrombocytopenia with a negative Coombs test and damage to target organs such as the heart, kidneys, lungs, and central nervous system. 4 There are three main types of TMA: thrombotic thrombocytopenic purpura (TTP), hemolyticuremic syndrome (HUS), and atypical hemolytic-uremic syndrome (aHUS).…”
Section: Introductionmentioning
confidence: 99%