New-Onset Crohn’s Disease following Initiation of Secukinumab: A Case Report and Review of the Role of IL-17 in the Pathogenesis of Crohn’s Disease

Khouri, Anas; Moreno, C.; Niland, Benjamin

doi:10.1155/2023/1769290

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Within this context, other cytokines such as IL-1, IL-6, IL-23, and transforming growth factor-beta (TGF-β) contribute to the differentiation of a Th17 profile during the antigen presentation process among a subset of immature lymphocytes[ 27 ]. These cells are responsible for synthesizing IL-17, which stimulates the migration and activity of neutrophils, thereby promoting a more inflammatory environment, along with T regulatory (T-reg) cells[ 27 , 28 ]. Furthermore, the high levels of IL-17 present in the tissues affected by CD can act on the intestinal epithelium, triggering the release of chemokines that further enhance the chemotaxis of inflammatory agents[ 28 , 29 ].…”

Section: Pathophysiology and Crohn’s Disease Immunologymentioning

confidence: 99%

“…These cells are responsible for synthesizing IL-17, which stimulates the migration and activity of neutrophils, thereby promoting a more inflammatory environment, along with T regulatory (T-reg) cells[ 27 , 28 ]. Furthermore, the high levels of IL-17 present in the tissues affected by CD can act on the intestinal epithelium, triggering the release of chemokines that further enhance the chemotaxis of inflammatory agents[ 28 , 29 ]. Macrophages and antigen-presenting cells (APC) also contribute to the synthesis of IL-12, IL-6, TGF-β, and IL-23.…”

Section: Pathophysiology and Crohn’s Disease Immunologymentioning

confidence: 99%

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Crohn's disease and clinical management today: How it does?

da Silva Júnior,

Apolonio,

de Souza Nascimento

et al. 2023

World J Methodol

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Crohn’s Disease (CD) is an Inflammatory Bowel Disease and is characterized by an immune-mediated nature. Its etiology results from the interaction between genetic, enviromental and microbial factors. Regarding pathophysiology, it involves high levels of interleukin (IL)-12, IL-17, and Th1 profile, along with loss of tolerance mechanisms, an increase in pro-inflammatory interleukins, beyond the possibility to affect any part of the gastrointestinal tract. Its symptoms include abdominal pain, chronic diarrhea, weight loss, anorexia, and fatigue, as well as blood in the stool or rectum. Additionally, conditions comprising musculoskeletal, cutaneous, ocular, hepatic, and hematological alterations may be associated with this scenario and extra-intestinal presentation, such as erythema nodosum, anterior uveitis, osteoporosis, and arthritis can also occur. Today, clinical history, exams as fecal calprotectin, ileocolonocopy, and capsule endoscopy can be performed in the diagnosis investigation, along with treatments to induce and maintain remission. In this sense, anti-inflammatory drugs, such as corticosteroids, immunomodulators, and biological agents, as well as surgery and non-pharmacological interventions plays a role in its therapy. The aim of this review is to bring more current evidence to clinical management of CD, as well as to briefly discuss aspects of its pathophysiology, surveillance, and associated disorders.

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Section: Pathophysiology and Crohn’s Disease Immunologymentioning

confidence: 99%

Section: Pathophysiology and Crohn’s Disease Immunologymentioning

confidence: 99%

Crohn's disease and clinical management today: How it does?

da Silva Júnior,

Apolonio,

de Souza Nascimento

et al. 2023

World J Methodol

View full text Add to dashboard Cite

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Drug-induced entero-colitis due to interleukin-17 inhibitor use; capsule endoscopic findings and pathological characteristics: A case report

Saito,

Yoza,

Takeda

et al. 2023

World J Gastroenterol

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The robotic liver resection (RLR) has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system, however, controversies still exist. Based on the foundation of the previous consensus statement, this new consensus document aimed to update clinical recommendations and provide guidance to improve the outcomes of RLR clinical practice. The guideline steering group and guideline expert group were formed by 29 international experts of liver surgery and evidence-based medicine (EBM). Relevant literature was reviewed and analyzed by the evidence evaluation group. According to the WHO Handbook for Guideline Development, the Guidance Principles of Development and Amendment of the Guidelines for Clinical Diagnosis and Treatment in China 2022, a total of 14 recommendations were generated. Among them were 8 recommendations formulated by the GRADE method, and the remaining 6 recommendations were formulated based on literature review and experts’ opinion due to insufficient EBM results. This international experts consensus guideline offered guidance for the safe and effective clinical practice and the research direction of RLR in future.

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New-Onset Crohn’s Disease following Initiation of Secukinumab: A Case Report and Review of the Role of IL-17 in the Pathogenesis of Crohn’s Disease

Cited by 2 publications

References 11 publications

Crohn's disease and clinical management today: How it does?

Crohn's disease and clinical management today: How it does?

Drug-induced entero-colitis due to interleukin-17 inhibitor use; capsule endoscopic findings and pathological characteristics: A case report

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