New-Onset Diabetes After Transplantation 2003 International Consensus Guidelines

Davidson, Jaime A.; Wilkinson, Alan H.

doi:10.2337/diacare.27.3.805

Cited by 318 publications

(470 citation statements)

References 51 publications

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“…Important risk factors include age, ethnic background, obesity, tacrolimus, prednisone and hepatitis C viral infection (2,(6)(7)(8)(9)(10). Because of its immense impact on clinical outcomes, prevention of new-onset diabetes is highly desirable.…”

Section: Introductionmentioning

confidence: 99%

“…Statins may improve insulin resistance even in nondiabetic patients (16), and may actually have a protective effect against the development of diabetes in the general population (17). We therefore hypothesized that statins would demonstrate a protective effect against new-onset diabetes in renal transplant recipients (RTR), whose risk factors for diabetes are well defined (2,10) and somewhat different (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

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Reduced Incidence of New-Onset Diabetes Mellitus after Renal Transplantation with 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitors (Statins)

Prasad

Kim

Huang

et al. 2004

American Journal of Transplantation

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Reduced Incidence of New-Onset Diabetes Mellitus after Renal Transplantation with 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitors (Statins)

Prasad

Kim

Huang

et al. 2004

American Journal of Transplantation

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“…Furthermore, PTDM is not always permanent and may resolve within weeks or months, sometimes without treatment (11). Although several recent reports on a consensus definition of PTDM have been published (5,8,12,13), there are still few studies about the long-term course of PTDM (14).…”

Section: Diabetes Care 30:609 -615 2007mentioning

confidence: 99%

Risk Factors Associated With the Onset and Progression of Posttransplantation Diabetes in Renal Allograft Recipients

Hur

Kim

et al. 2007

Diabetes Care

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OBJECTIVE -The aim of this study was to assess the incidence of posttransplantation diabetes mellitus (PTDM) in renal allograft recipients and to investigate factors contributing to the onset and progression of PTDM and its underlying pathogenic mechanism(s).RESEARCH DESIGN AND METHODS -A total of 77 patients with normal glucose tolerance (NGT) were enrolled in this study. An oral glucose tolerance test was performed 1 week before transplantation and repeated at 1 and 7 years after transplantation.RESULTS -The overall incidence of PTDM was 39% at 1 year and 35.1% at 7 years posttransplantation. The incidence for each category of PTDM was as follows: persistent PTDM (P-PTDM) (patients who developed diabetes mellitus within 1 year of transplantation and remained diabetic during 7 years), 23.4%; transient PTDM (T-PTDM) (patients who developed diabetes mellitus during the 1st year after transplantation but eventually recovered to have NGT), 15.6%; late PTDM (L-PTDM) (patients who developed diabetes mellitus later than 1 year after transplantation), 11.7%; and non-PTDM during 7 years (N-PTDM 7 ) (patients who did not develop diabetes mellitus during 7 years), 49.3%. Older age (Ն40 years) at transplantation was a higher risk factor for P-PTDM, whereas a high BMI (Ն25 kg/m 2 ) and impaired fasting glucose (IFG) at 1 year posttransplantation were higher risk factors for L-PTDM. Impaired insulin secretion rather than insulin resistance was significantly associated with the development of Pand L-PTDM.CONCLUSIONS -Impaired insulin secretion may be the main mechanism for the development of PTDM. Older age at transplantation seems to be associated with P-PTDM, whereas a high BMI and IFG at 1 year after transplantation were associated with L-PTDM. Diabetes Care 30:609 -615, 2007P osttransplantation diabetes mellitus (PTDM) is a major complication after kidney transplantation and can lead to a wide range of complications including graft loss, increased mortality, increased number of rejections, and increased risk of cardiovascular disease (1-4). A recent meta-analysis of observational studies and randomized, controlled trials showed that the incidence of PTDM during the 1st year after transplantation varied from 2 to 50% (5). There have been several previous reports on PTDM in Korean patients, albeit for a short period of observation. We reported previously that the incidence of PTDM was 23.7% in 114 patients treated with cyclosporine A (CsA) at 9 -12 months after transplantation (6), whereas Cho et al. (7) reported that it was 57.1% in 21 patients treated with tacrolimus at 6 months after transplantation in Korea.PTDM and type 2 diabetes are similar in many ways. One example is that the onset of both can be insidious (8); individuals may experience glucose intolerance and remain asymptomatic for years before symptoms manifest clinically (9,10). Furthermore, PTDM is not always permanent and may resolve within weeks or months, sometimes without treatment (11). Although several recent reports on a consensus definition of PTDM ha...

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“…Systemic arterial hypertension was defined as a repeated elevated blood pressure exceeding 140 x 90 mmHg or when patients were using at least one antihypertensive drug. New onset of diabetes after transplantation was defined when fasting plasma glucose was ≥126 mg/dL (≥7 mM), when a random blood sugar level ≥200 mg/dL (≥11.1 mM) was detected, accompanied by symptoms, or an oral glucose tolerance test value ≥200 mg/dL (12). Renal function was measured by serum creatinine and by creatinine clearance calculated with the Cockcroft-Gault equation.…”

Section: Operational Definitionsmentioning

confidence: 99%

“…Biopsy specimens of all cases were evaluated and graded according to the Banff 05 criteria (12 and TA (>50% of cortical area; may include non-specific vascular and glomerular sclerosis, but severity is graded by tubulointerstitial features). At least four stained slides were used to quantify histological changes in each biopsy, one stained with hematoxylin-eosin, one with Masson's trichrome, one with periodic acid-Schiff, and one with silver.…”

Section: Histological Analysesmentioning

confidence: 99%

Glomerular damage as a predictor of renal allograft loss

Moscoso-Solorzano

Câmara

Franco

et al. 2010

Braz J Med Biol Res

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New-Onset Diabetes After Transplantation 2003 International Consensus Guidelines

Cited by 318 publications

References 51 publications

Reduced Incidence of New-Onset Diabetes Mellitus after Renal Transplantation with 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitors (Statins)

Reduced Incidence of New-Onset Diabetes Mellitus after Renal Transplantation with 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitors (Statins)

Risk Factors Associated With the Onset and Progression of Posttransplantation Diabetes in Renal Allograft Recipients

Glomerular damage as a predictor of renal allograft loss

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