New-onset headache following COVID-19: An Italian multicentre case series

Torrente, Angelo; Alonge, Paolo; Stefano, Vincenzo Di; Baschi, Roberta; Ornello, Raffaele; Correnti, Edvige; Lupica, Antonino; Camarda, Cecilia; Farinella, Gabriella; Raieli, Vincenzo; Sacco, Simona; Monastero, Roberto; Brighina, Filippo

doi:10.1016/j.jns.2023.120591

Cited by 11 publications

(7 citation statements)

References 23 publications

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“…Following COVID-19, new-onset headaches are a diverse disorder with a murky pathophysiology. With a wide range of symptoms (the New Daily Persistent Headache being the most prevalent one) and a varied response to therapy, this form of headache can become chronic and severe ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

Post-COVID-19 headache- NDPH phenotype: a systematic review of case reports

Dhiman,

Joshi,

Singh

et al. 2024

Front. Pain Res.

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Background and objectivesPost-acute COVID-19 syndrome or “long COVID” affects patients even after the recovery from Covid infection in various ways. Persistent headache or New Daily Persistent Headache (NDPH) is one of such symptoms. In this review, we will discuss about the case-reports of post covid-19 headache- NDPH phenotype both after and in the course of COVID-19 infection.MethodsCase reports/studies talked about patients having NDPH around the disease either immediately or late post COVID were included. Data was taken from the source and synthesised on a qualitative basis.ResultsLiterature search showed 3,538 articles, out of which 12 were screened as per the eligibility criteria and finally, 4 case reports on NDPH and Covid-19 were chosen for analysis from the database and by human search. All case reports justify the criteria for acceptability in quality for this systematic review.ConclusionNDPH in and around Covid 19 infection is something that is currently an ingenious debated topic in the scientific community. More case studies should be written and published on the same subject so that a large systematic review could be conducted.Trial Registration InformationThe review is registered in Prospero with no. Identifier (CRD42022354912).Systematic Review Registrationhttps://www.crd.york.ac.uk/, PROSPERO (CRD42022354912).

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Section: Discussionmentioning

confidence: 99%

Post-COVID-19 headache- NDPH phenotype: a systematic review of case reports

Dhiman,

Joshi,

Singh

et al. 2024

Front. Pain Res.

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“…Conversely, race was determined according to the participant's self-perception, showing a predominance of mixed and white race, in contrast to other studies showing a predominance of only white race [23-25, 34, 38]. To date, the only large study assessing speci cally NDPH and COVID-19 is a case series from Italy [35]. Out of a series of 11 patients with persistent headaches, only eight patients met the inclusion criteria for NDPH (36.4%) or probable NDPH (36.4%).…”

Section: Discussionmentioning

confidence: 99%

“…Then, more studies of probable NDPH cases in adults along with SARS-CoV-2 infection [12,15] and in children and adolescents [18] have followed. The most recent study being a comprehensive multicenter case series from Italy [35].…”

Section: Discussionmentioning

confidence: 99%

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New daily persistent headache after SARS-CoV-2 infection in Latin America: a cross- sectional study

Carrión-Nessi,

Ascanio,

Pineda-Arapé

et al. 2023

Preprint

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Background Persistent headache is a frequent symptom after coronavirus disease 2019 (COVID-19) and there is currently limited knowledge about its clinical spectrum and predisposing factors. A subset of patients may be experiencing new daily persistent headache (NDPH) after COVID-19, which is among the most treatment-refractory primary headache syndromes.Methods We conducted a cross-sectional study in Latin America to characterize individuals with persistent headache after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and identify risk factors associated with NDPH. Participants over 18 years old who tested positive for SARS-CoV-2 infection and reported persistent headache among their symptoms completed an online survey that included demographics, past medical history, persistent headache clinical characteristics, and COVID-19 vaccination status. Based on participants’ responses, NDPH diagnostic criteria were used to group participants into NDPH and non-NDPH groups.Results Four hundred and twenty-one participants from 11 Latin American countries met the inclusion criteria. One in four participants met the diagnostic criteria for NDPH. The mean age was 40 years, with most participants being female (82%). Over 90% of the participants reported having had mild/moderate COVID-19. Most participants had a history of headache before developing COVID-19 (58%), mainly migraine type (32%). The most predominant clinical characteristics in the NDPH group were occipital location, severe/unbearable intensity, burning character, and radiating pain (p < 0.05). A higher proportion of anxiety symptoms, sleep problems, myalgia, mental fog, paresthesia, nausea, sweating of the face or forehead, and ageusia or hypogeusia as concomitant symptoms were reported in participants with NDPH (p < 0.05). Palpebral edema as a concomitant symptom during the acute phase of COVID-19, occipital location, and burning character of the headache were risk factors associated with NDPH.Conclusion This is the first study in Latin America that explored the clinical spectrum of NDPH after SARS-CoV-2 infection and its risk factors. Clinical evaluation of COVID-19 patients presenting with persistent headache should take into consideration NDPH.

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“…Notably, it also emerges as a primary symptom observed in the post-COVID-19, with a prevalence of 10% (1). Interestingly, some patients without a history of previous headacherelated disorders experience new-onset headaches following SARS-CoV-2 infection (2). The presence of headache in the acute phase of COVID-19 is associated with a higher prevalence of long-term post-COVID headache (3).…”

Section: Introductionmentioning

confidence: 99%

Altered metabolites in the periaqueductal gray of COVID-19 patients experiencing headaches: a longitudinal MRS study

Jin,

Cui,

Zhang

2024

Front. Neurol.

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BackgroundHeadache is one of the most common symptoms of acute COVID-19 infection. However, its mechanisms remain poorly understood, and there is a lack of studies investigating changes in the periaqueductal gray (PAG) in COVID-19 patients exhibiting headaches.PurposeThe study aimed to explore the alterations in metabolites of the PAG pre- and post-COVID-19 infection in individuals who suffered from headaches during the acute phase of the disease using proton magnetic resonance spectroscopy (1H-MRS).MethodsFifteen participants who experienced headaches during the acute phase of COVID-19 were recruited. All subjects underwent two proton magnetic resonance spectroscopy (1H-MRS) examinations focusing on the PAG before and after they were infected. Metabolite changes were assessed between the pre- and post-infection groups.ResultsThe combined glutamine and glutamate/total creatine ratio (Glx/tCr) was increased in the PAG following COVID-19 infection. The total choline/total creatine ratio (tCho/tCr) in the pre-infection group was negatively correlated with the duration of headache during the COVID-19 acute phase.ConclusionThe present study indicates that PAG plays a pivotal role in COVID-19 headaches, thereby supporting the involvement of trigeminovascular system activation in the pathophysiology of COVID-19 headaches.

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New-onset headache following COVID-19: An Italian multicentre case series

Cited by 11 publications

References 23 publications

Post-COVID-19 headache- NDPH phenotype: a systematic review of case reports

Post-COVID-19 headache- NDPH phenotype: a systematic review of case reports

New daily persistent headache after SARS-CoV-2 infection in Latin America: a cross- sectional study

Altered metabolites in the periaqueductal gray of COVID-19 patients experiencing headaches: a longitudinal MRS study

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