New Onset Hypertension After Extracorporeal Shock Wave Lithotripsy: Age Related Incidence and Prediction by Intrarenal Resistive Index

Janetschek, Günter; Frauscher, Ferdinand; Knapp, Rudolf; Höfle, Günter; Peschel, Reinhard; Bartsch, Georg

doi:10.1016/s0022-5347(01)64475-6

Cited by 116 publications

(66 citation statements)

References 27 publications

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“…When we evaluated VRI using Doppler ultrasound, a significant increase in VRI was seen after ESWL. These findings are in agreement with Janetschek et al [26], who found increased VRI in the treated kidneys of patients who underwent ESWL. In addition, this overexpression of renin with a subsequent increase in angiotensin promotes the release of oxygen-free radicals (OFR) via activation of the NADPH oxidase, with the resulting activation of pro-inflammatory molecules that contribute to kidney damage [27].…”

Section: Eswl Associated Injurysupporting

confidence: 93%

The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial

et al. 2014

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These results are protected by a patent at the Spanish Office of Patents and Trademarks (Reference: P201131992) Objective• To determine the efficacy of coenzyme Q10 (CoQ10) in preventing renal injury in patients with lithiasis undergoing extracorporeal shockwave lithotripsy (ESWL). Patients and Methods• Prospective, randomised, double-blind, placebo-controlled clinical trial of 100 patients with renal lithiasis who were treated with ESWL.• The patients were distributed randomly into two groups receiving either placebo or CoQ10 (200 mg/day), a powerful antioxidant with vasoactive properties, orally administered during the week before ESWL and for 1 week after.• Renal dysfunction markers, vasoactive hormones, oxidative stress, plasma levels of several interleukins and vascular resistance index (VRI) using Doppler ultrasound were evaluated the week before ESWL, 2 h before ESWL and at 2 h, 24 h and 7 days after ESWL. Results• There was a significant increase in glomerular filtration (P = 0.013), as well as a decrease in the albumin/creatinine ratio and the β2-microglobulin level (P = 0.02) after 1 week of treatment in the CoQ10 group. These changes were maintained at the follow-up after ESWL.• The administration of CoQ10 was associated with improvement in vasoactive hormone parameters, VRI and interleukin levels. These improvements were maintained until the end of the follow-up period.• However, the administration of CoQ10 was not associated with significant changes in the oxidative stress parameters. Conclusion• Our results indicate that CoQ10 administration improves renal function and vasoactive and inflammation parameter values, allowing for preconditioning before the tissue insult caused by ESWL.

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Section: Eswl Associated Injurysupporting

confidence: 93%

The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial

et al. 2014

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“…Even longer term follow-up suggests that the risk for an elevated serum creatinine level is not increased with SWL compared with percutaneous nephrolithotomy or conservative management (33). Hypertension has been described as a complication of SWL in many (34,35) but not all (32,36,37) studies. A recent population-based study did not find an increased risk with developing hypertension, suggesting that this complication is not common with most stone formers who undergo SWL (38).…”

Section: Putative Mechanisms For Ckd In Stone Formersmentioning

confidence: 99%

Chronic Kidney Disease in Kidney Stone Formers

Rule¹,

Krambeck²,

Lieske³

2011

Clinical Journal of the American Society of Nephrology

184

120

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SummaryRecent population studies have found symptomatic kidney stone formers to be at increased risk for chronic kidney disease (CKD). Although kidney stones are not commonly identified as the primary cause of ESRD, they still may be important contributing factors. Paradoxically, CKD can be protective against forming kidney stones because of the substantial reduction in urine calcium excretion. Among stone formers, those with rare hereditary diseases (cystinuria, primary hyperoxaluria, Dent disease, and 2,8 dihydroxyadenine stones), recurrent urinary tract infections, struvite stones, hypertension, and diabetes seem to be at highest risk for CKD. The primary mechanism for CKD from kidney stones is usually attributed to an obstructive uropathy or pyelonephritis, but crystal plugs at the ducts of Bellini and parenchymal injury from shockwave lithotripsy may also contribute. The historical shift to less invasive surgical management of kidney stones has likely had a beneficial impact on the risk for CKD. Among potential kidney donors, past symptomatic kidney stones but not radiographic stones found on computed tomography scans were associated with albuminuria. Kidney stones detected by ultrasound screening have also been associated with CKD in the general population. Further studies that better classify CKD, better characterize stone formers, more thoroughly address potential confounding by comorbidities, and have active instead of passive follow-up to avoid detection bias are needed.

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“…Patients over the age of 60 may develop hypertension at a higher rate than the control population, which can be predicted by increased intra renal resistive indices. Close postoperative screening for hypertension in the older patients is recommended [31].…”

Section: Eswl and Hypertensionmentioning

confidence: 99%

The role of extracorporeal shock wave lithotripsy in renal calculi

Perera¹,

Perera

2014

Sri Lanka j Surg

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New Onset Hypertension After Extracorporeal Shock Wave Lithotripsy: Age Related Incidence and Prediction by Intrarenal Resistive Index

Abstract: Patients older than 60 years are at risk for disturbances of renal perfusion as assessed by the resistive index, and 45% of these patients have new onset hypertension within 26 months of treatment.

Cited by 116 publications

References 27 publications

The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial

The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial

Chronic Kidney Disease in Kidney Stone Formers

The role of extracorporeal shock wave lithotripsy in renal calculi

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