New‐onset lichen planus and lichen planus flare in elderly women after COVID‐19 vaccination

Abstract

Owing to the widespread use of COVID-19 vaccines, the number of cutaneous vaccine-related adverse events has recently increased. 1 We present two cases of lichen planus in elderly women following COVID-19 mRNA vaccination. The first patient presented with new-onset LP, whereas the second patient experienced an extensive LP flare after a 10-year remission.The first patient was an 82-year-old woman who developed an extensive pruritic rash 14 days after receiving a second dose of the Pfizer-BioNTech COVID-19 vaccine. Other possible triggers such as recent infections, medication changes, or stressful events preceding the eruption were ruled out. The patient had no significant medical history, other than well-controlled arterial hypertension. On physical examination, she had polygonal, purpuric, scaly papules in the axillary region, flexural wrists and forearms, ankles, buttocks, lower back, and abdomen (Figure 1). Mucosal lesions were not observed. Dermoscopy revealed mild desquamation and

Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature

“…61 To date, 13 cases of new-onset cutaneous lichen planus and 3 cases of cutaneous lichen planus exacerbation have been reported. [62][63][64][65][66][67][68][69][70][71][72][73][74][75][76] Like psoriasis, also cases of new onset and flare of atopic dermatitis or eczema have been reported (7 and 14, respectively). [77][78][79][80][81][82][83] However, there is not a clear correlation with clinical phenotypes.…”

“… BNT162b2: 10 mRNA-1273: 3 AZD1222: 3 Ad26.COV2: 1 Flare of psoriasis 81 Huang et al 29 (15), Sotiriou et al 30 (14), Koumaki et al 31 (12), Megna et al 32 (11), Wei et al 53 (6), Ruggiero et al 26 (4), Durmaz et al 33 (2), Tran et al 34 (2), Piccolo et al 36 (2), Bostan et al 37 (1), Nagrani et al 35 (1), Pavia et al 38 (1), Durmus et al 39 (1), Fang et al 40 (1), Krajewski et al 41 (1), Trepanowski et al 42 (1), Mieczkowska et al 43 (1), Lopez et al 44 (1), Perna et al 45 (1), Tsunoda et al 47 (1), Nia et al 48 (1), Pesqué et al 28 (1). BNT162b2: 43 mRNA-1273: 17 AZD1222: 21 Ad26.COV2: 0 Cutaneous lichen planus 16 New-onset: Merhy et al 62 (1), Camela et al 63 (1), Kato et al 69 (1), Diab et al 70 (1), Zagaria et al 71 (1), Awada et al 72 (1), Picone et al 73 (1), Hlaca et al 74 (1), Zengarini et al 75 (1), Masseran et al 76 (1), Gamonal et al 64 (1), Alrawashdeh et al 65 (1), Shakoei et al 66 (1). Flare: Hiltun et al 67 (1), Herzum et al 68 (1), Hlaca et al 74 (1).…”

“… BNT162b2: 43 mRNA-1273: 17 AZD1222: 21 Ad26.COV2: 0 Cutaneous lichen planus 16 New-onset: Merhy et al 62 (1), Camela et al 63 (1), Kato et al 69 (1), Diab et al 70 (1), Zagaria et al 71 (1), Awada et al 72 (1), Picone et al 73 (1), Hlaca et al 74 (1), Zengarini et al 75 (1), Masseran et al 76 (1), Gamonal et al 64 (1), Alrawashdeh et al 65 (1), Shakoei et al 66 (1). Flare: Hiltun et al 67 (1), Herzum et al 68 (1), Hlaca et al 74 (1). BNT162b2: 8 mRNA-1273: 1 AZD1222: 7 Ad26.COV2: 0 New-onset atopic dermatitis/eczema 7 Rerknimitr et al 77 (3), Holmes et al 78 (1), Leasure et al 79 (1), Bekkali et al 80 (1), Larson et al 81 (1).…”

“…(1). Merhy et al62 (1), Camela et al63 (1), Kato et al69 (1), Diab et al70 (1), Zagaria et al71 (1), Awada et al72 (1), Picone et al73 (1), Hlaca et al74 (1), Zengarini et al75 (1), Masseran et al76 (1), Gamonal et al64 (1), Alrawashdeh et al65 (1), Shakoei et al66 (1). Zou et al122 (3), Gui et al123 (2), Rouatbi et al124 (2), Aryanian et al125 (1), Koutlas et al126 (1), Knechtl et al127 (1), Ong et al128 (1), Yıldırıcı et al129 (1), Singh et al130 (1), Norimatsu et al131 (1), Agharbi et al132 (1), Almasi-Nasrabadi et al133 (1),…”

“…Flare: Hiltun et al67 (1), Herzum et al68 (1), Hlaca et al74 (1) 82 (11),. Leasure et al79 (1), Niebel et al83 (1), Larson et al81 (1) 94 (39),.…”