New Onset of Constipation during Long-Term Physical Inactivity: A Proof-of-Concept Study on the Immobility-Induced Bowel Changes

Iovino, Paola; Chiarioni, Giuseppe; Bilancio, Giancarlo; Cirillo, Massimo; Mekjavic, Igor B.; Pišot, Rado; Ciacci, Carolina

doi:10.1371/journal.pone.0072608

Cited by 75 publications

(55 citation statements)

References 41 publications

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“…[21,22] Even though those ndings have been described in chronically ill patients, little is known about reduced mobility and the appearance of constipation in a population that previously was apparently healthy, such as the one we evaluated. Our results are similar to those reported by Iovino et al, [15] in a "new-onset" constipation model. Those authors demonstrated that strict bedrest for a period of 35 days, adhered to even to perform daily activities, including defecation, was associated with a high rate of constipation in healthy volunteers.…”

Section: Discussionsupporting

confidence: 93%

“…[11,13,14] Symptoms of constipation induced by immobility in geriatric patients have been shown to decrease with the regular performance of physical activity. In a unique study on the subject, Iovino et al [15] demonstrated that prolonged physical inactivity (for 35 days, in 10 healthy volunteers) triggered constipation in 60% of the study individuals.…”

Section: Introductionmentioning

confidence: 99%

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Incidence of “new-onset” constipation and associated factors during lockdown due to the coronavirus-19 pandemic.

Remes-Troche

Coss‐Adame

Amieva-Balmori

et al. 2020

Preprint

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Background: A minimum of physical activity and low liquid intake are factors that have been associated with constipation. The health emergency brought on by the COVID-19 pandemic has resulted in adopting behavior, such as sheltering-in-place (less mobility) and dietary changes, creating a scenario we believe to be an adequate model for examining the appearance of symptoms of constipation and its associated factors. Methods: A cross-sectional and descriptive study was conducted on an open population, applying an electronic survey (4 weeks after lockdown due to COVID-19 in Mexico) to evaluate: demographic characteristics, physical activity, water and fiber intake, appearance of constipation symptoms (including stool consistency), and quality of life.Key results: Out of 678 subjects evaluated, 170 (25%, 95% CI 21.7-28.4) developed symptoms of “new-onset” constipation, with a significant decrease in the number of daily bowel movements (p<0.05) and hardness of stool consistency (p<0.05) during lockdown. The multivariate analysis (logistic regression) showed that female sex (p=0.001), water intake (p=0.039), and physical activity (p=0.012) were associated with “new-onset” constipation. Conclusions: Reduced physical activity and less water intake due to mobility restrictions imposed for epidemiologic reasons, such as a pandemic, can lead to symptoms of “new-onset” constipation.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Incidence of “new-onset” constipation and associated factors during lockdown due to the coronavirus-19 pandemic.

Remes-Troche

Coss‐Adame

Amieva-Balmori

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Therefore, careful attention to diet and exercise need to be looked after in order to prevent an impaction on the bowel problem from recurring. Moreover, there was a study that indicated FC will arise from physical inactivity, even among healthy individuals [52]. …”

Section: Discussionmentioning

confidence: 99%

The Prevalence and Symptoms Characteristic of Functional Constipation Using Rome III Diagnostic Criteria among Tertiary Education Students

et al. 2016

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Background and AimsFunctional constipation is very common with heterogeneous symptoms that have substantial impact on patient quality of life as well as medical resources which are rarely reported as life-threatening. The aim of this study is to examine the prevalence and symptoms characteristic of functional constipation (FC) by using Rome III diagnostic criteria among tertiary education students with an intention to introduce treatment in the future.MethodsDemographic, socio-economics characteristics and symptoms of FC using the Rome III criteria were sought using a questionnaire administered to Malaysian students in a tertiary education setting. Other data obtained were the general health status, lifestyle factors and anthropometric measurements. Using a simple random sampling method, a total of 1662 students were recruited in the study with a response rate of 95.0%. Sampled data are presented as frequency and percentage and stratified accordingly into categories for Chi-square analysis.ResultsThe prevalence of functional constipation among the students was 16.2%, with a significantly higher prevalence among women (17.4%) than men (12.5%). Hard or lumpy stool, incomplete evacuation, anorectal obstruction and straining were reported as the commonest symptoms experienced. Type 3 was the most frequent stool consistency experienced among the constipated individuals (35.2%). Only 4.4% of individuals reported having less than three defecations per week. Using univariable analysis, FC was significantly associated with sex (odds ratio: 1.48, 95% CI: 1.06–2.06) and age group (odds ratio: 1.34, 95% CI: 1.01–1.79) with P value < 0.05 significance level. In multivariate logistic regression analysis, only sex was found significantly associated with FC (adjusted odds ratio: 1.53, 95% CI: 1.08–2.17, P < 0.05).ConclusionsBased on the prevalence rate, constipation is a common problem among tertiary education students (16.2%), with significantly more prevalence among the female respondents. Early detection of symptoms and further intervention studies focusing on treatment recommendation in improving the symptoms are essential.

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“…It has been previously suggested that anorectal dysfunction underlying functional constipation may be an important contributory factor to the development of bloating and abdominal distension [62] . We found that in healthy men who underwent experimentally-controlled 35-d of bed rest, at the end of the study, 60% had new onset of functional constipation fulfilling Rome Ⅲ criteria, moreover, there was a significant increase in flatulence and a significant correlation between the change in flatulence and the change in number of evacuations that significantly decreased [63] . It is possible that during bed rest due to an ineffective evacua- Figure 2 Gas physiology in the gastrointestinal tract.…”

Section: Stoolsmentioning

confidence: 79%

Bloating and functional gastro-intestinal disorders: Where are we and where are we going?

Iovino

Bucci

Tremolaterra

et al. 2014

WJG

Self Cite

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Bloating is one of the most common and bothersome symptoms complained by a large proportion of patients. This symptom has been described with various definitions, such as sensation of a distended abdomen or an abdominal tension or even excessive gas in the abdomen, although bloating should probably be defined as the feeling (e.g. a subjective sensation) of increased pressure within the abdomen. It is usually associated with functional gastrointestinal disorders, like irritable bowel syndrome, but when bloating is not part of another functional bowel or gastrointestinal disorder it is included as an independent entity in Rome Ⅲ criteria named functional bloating. In terms of diagnosis, major difficulties are due to the lack of measurable parameters to assess and grade this symptom. In addition, it is still unclear to what extent the individual patient complaint of subjective bloating correlates with the objective evidence of abdominal distension. In fact, despite its clinical, social and economic relevance, bloating lacks a clear pathophysiology explanation, and an effective management endorsement, turning this common symptom into a true challenge for both patients and clinicians. Different theories on bloating etiology call into questions an increased luminal contents (gas, stools, liquid or fat) and/or an impaired abdominal empting and/or an altered intra-abdominal volume displacement (abdomino-phrenic theory) and/ or an increased perception of intestinal stimuli with a subsequent use of empirical treatments (diet modifications, antibiotics and/or probiotics, prokinetic drugs, antispasmodics, gas reducing agents and tricyclic antidepressants). In this review, our aim was to review the latest knowledge on bloating physiopathology and therapeutic options trying to shed lights on those processes where a clinician could intervene to modify disease course. Key words: Bloating; Functional gastro-intestinal disorders; Irritable bowel syndrome; Constipation; Diarrhea Core tip: Bloating is one of the most common and bothersome symptoms complained by a large proportion of patients, mostly with functional gastrointestinal disorders, but when bloating is not part of another functional bowel or gastrointestinal disorder it is included as an independent entity in Rome Ⅲ criteria named functional bloating. Despite its clinical, social and economic Iovino P et al . Bloating and functional gastro-intestinal disorders relevance, bloating lacks a clear pathophysiology explanation and an effective management endorsement. Moreover, it is unclear to what extent subjective complaint of bloating correlates with the objective evidence of abdominal distension. The aim of this paper is to review the latest knowledge on bloating and to explore future research directions to improve its management.

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New Onset of Constipation during Long-Term Physical Inactivity: A Proof-of-Concept Study on the Immobility-Induced Bowel Changes

Cited by 75 publications

References 41 publications

Incidence of “new-onset” constipation and associated factors during lockdown due to the coronavirus-19 pandemic.

Incidence of “new-onset” constipation and associated factors during lockdown due to the coronavirus-19 pandemic.

The Prevalence and Symptoms Characteristic of Functional Constipation Using Rome III Diagnostic Criteria among Tertiary Education Students

Bloating and functional gastro-intestinal disorders: Where are we and where are we going?

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