New onset of herpes simplex virus epithelial keratitis after penetrating keratoplasty

Rezende, Renata A.; Uchoa, Uchoandro B.C.; Raber, Irving M.; Rapuano, Christopher J.; Laibson, Peter R.; Cohen, Elisabeth J.

doi:10.1016/j.ajo.2003.09.057

Cited by 47 publications

(36 citation statements)

References 21 publications

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“…A randomized, placebo-controlled clinical trial demonstrated a significantly reduced recurrence rate following twice daily oral acyclovir during a 1-year observation period [11]; long-term acyclovir therapy is known to significantly improve graft outcomes [27] and prevent viral recurrences [29]. Early diagnosis of HSV keratitis is also important in corneal allograft recipients, and HSV keratitis has been described in patients with no history of herpes disease [4,23]. For these reasons, a clear diagnosis is mandatory in patients with suspected herpes keratitis undergoing penetrating keratoplasty or recurrent keratitis.…”

Section: Introductionmentioning

confidence: 99%

Specific antibody production in herpes keratitis: intraocular inflammation and corneal neovascularisation as predicting factors

Robert

Liekfeld

Metzner

et al. 2005

Graefe's Arch Clin Exp Ophthalmo

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Section: Introductionmentioning

confidence: 99%

Specific antibody production in herpes keratitis: intraocular inflammation and corneal neovascularisation as predicting factors

Robert

Liekfeld

Metzner

et al. 2005

Graefe's Arch Clin Exp Ophthalmo

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“…Whether newly acquired or reactivated, published reports have described dendritic keratitis after penetrating keratoplasty (PK) [1][2][3][4] and reactivated HSV after laser-assisted keratomileusis. [5][6][7][8] Herpetic keratitis after cataract surgery, however, is a much less reported event.…”

mentioning

confidence: 98%

“…A total of 5 cases have been reported, including 1 case of an eye with previous PK for keratoconus. 4,9,10 All the cases denied prior herpetic disease, underwent uncomplicated cataract surgery, and were managed for herpetic epithelial keratitis, with earliest presentation noted at postoperative day 10. We report a unique case of new-onset, culture-proven HSV keratitis occurring on postoperative day 5 after uncomplicated cataract extraction.…”

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confidence: 99%

New-Onset Herpes Simplex Virus Keratitis After Cataract Surgery

Patel

Teng

Sperber

et al. 2009

Cornea

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We report the case of a 34-year-old man who had uncomplicated cataract surgery in his left eye. Medical history was significant for atopic dermatitis, requiring oral immunosuppressive medications. Two days after the surgery, the patient presented with pain, photophobia, decreased vision, and a small corneal abrasion. On postoperative day 5, the patient returned with left upper lid vesicular lesions and 2 corneal dendrites. Corrected vision was 20/100 OS, with intraocular pressure of 18 mm Hg and 1+ pigmented cells in the anterior chamber. Cultures of the lid lesions revealed herpes simplex virus (HSV) type 1. The patient was placed on oral acyclovir 800 mg 5 times a day. By day 8, the dendrites had resolved, and by day 15, the lid lesions healed over. HSV keratitis is an uncommon complication after cataract surgery. Ophthalmologists should be aware of the possibility of developing HSV keratitis even after the most routine cataract extraction.

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“…Surgical trauma is one of the various stimulants that can reactivate the virus and cause infection in a case with no previous history of herpetic eye disease. There are a few reports of new onset of herpetic keratitis after penetrating keratoplasty (Mannis et al 1991;Remeijer et al 1997;Borderie et al 2004;Rezende et al 2004), laserassisted keratomileusis (Davidorf 1998;Perry et al 2002;Levy et al 2005) and cataract surgery (Miyajima et al 2003;Barequet & Wasserzug 2007). We present five cases of new-onset HSV infection after ocular surgery that had an unusual clinical presentation.…”

Section: Introductionmentioning

confidence: 99%

Unusual clinical presentations of new‐onset herpetic eye disease after ocular surgery

Jhanji

Ferdinands

Sheorey

et al. 2010

Acta Ophthalmologica

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ABSTRACT.Purpose: To report five cases of new-onset herpetic eye disease with unusual presentation after ocular surgery. Methods: Herpetic eye disease was suspected in five cases, three after cataract surgery and two after lamellar corneal transplantation surgery. Of these, four cases presented within 2-6 weeks of surgery. The clinical presentation was in the form of an epithelial defect, suspected epithelial down growth, graft oedema with unexplained anterior chamber inflammation and graft-host interface infection. A swab for viral detection with real-time polymerase chain reaction was performed in all the described cases. Results: Herpes simplex disease was detected in all cases. All cases responded to the antiherpetic medications. Conclusions: Our study shows that new-onset herpetic eye disease may occur after cataract surgery and lamellar corneal transplantation, and a high index of suspicion may be necessary for the diagnosis in such cases.

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New onset of herpes simplex virus epithelial keratitis after penetrating keratoplasty

Cited by 47 publications

References 21 publications

Specific antibody production in herpes keratitis: intraocular inflammation and corneal neovascularisation as predicting factors

Specific antibody production in herpes keratitis: intraocular inflammation and corneal neovascularisation as predicting factors

New-Onset Herpes Simplex Virus Keratitis After Cataract Surgery

Unusual clinical presentations of new‐onset herpetic eye disease after ocular surgery

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