New Onset of Severe Plaque Psoriasis Following COVID-19 Vaccination: A Case Report

Abstract

A case of new onset of severe plaque psoriasis following COVID-19 vaccination was reported. A 63-year-old woman presented with multiple plaques for 2 months after the second dose of COVID-19 vaccination. Dermatological examination revealed diffuse erythematous papules and plaques on trunk and limbs. Her lesions responded well to the treatment of secukinumab 150 mg per week. In this case, we presented the potential association between COVID-19 vaccination and the onset of psoriasis. It is essential to recognize the possible adverse events as vaccination against COVID-19 continues worldwide.

Cytokine Modulators in Plaque Psoriasis – A Review of Current and Prospective Biologic Therapeutic Approaches

“… 14 Furthermore, there is at least one report of onset of generalized erythrodermic psoriasis and one report of onset of plaque psoriasis after COVID-19 vaccination. 15 , 16 In addition, there are numerous “inside-out” triggers, or those that are internal to the patient that elicit the psoriatic proinflammatory cascade. One of the primary inside-out culprits identified to-date is the keratinocyte, although numerous additional immune cells have also been implicated in the psoriasis etiology.…”

“… 17 Numerous other “outside-in” and “inside-out” triggers may also initiate the inflammatory response; they are omitted here for clarity. Damaged keratinocytes release numerous inflammatory mediators, 16 including TNF-α and ILs 1β, 6, 19, 20, and 36. Inflammatory mediators stimulate plasmacytoid dendritic cells, natural killer cells, and macrophages to produce numerous additional mediators, 18 , 19 which promote myeloid dendritic cell (mDC) maturation.…”