New opportunities and perspectives on biosynthesis and bioactivities of secondary metabolites from Aloe vera

Ushasree, Mrudulakumari Vasudevan; Jia, Qi; Do, Seon Gil; Lee, Eun Yeol

doi:10.1016/j.biotechadv.2024.108325

Biotechnology Advances

2024

DOI: 10.1016/j.biotechadv.2024.108325

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New opportunities and perspectives on biosynthesis and bioactivities of secondary metabolites from Aloe vera

Mrudulakumari Vasudevan Ushasree,

Qi Jia,

Seon Gil Do

et al.

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2024

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Cited by 5 publications

References 287 publications

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Plant‐derived extracellular vesicles (EVs) are promising therapeutic agents owing to their natural abundance, accessibility, and unique biological properties. This review provides a comprehensive exploration of the therapeutic potential of plant‐derived EVs and emphasizes their anti‐inflammatory, antimicrobial, and tumor‐inhibitory effects. Here, we discussed the advancements in isolation and purification techniques, such as ultracentrifugation and size‐exclusion chromatography, which are critical for maintaining the functional integrity of these nanovesicles. Next, we investigated the diverse administration routes of EVs and carefully weighed their respective advantages and challenges related to bioavailability and patient compliance. Moreover, we elucidated the multifaceted mechanisms of action of plant‐derived EVs, including their roles in anti‐inflammation, antioxidation, antitumor activity, and modulation of gut microbiota. We also discussed the impact of EVs on specific diseases such as cancer and inflammatory bowel disease, highlighting the importance of addressing current challenges related to production scalability, regulatory compliance, and immunogenicity. Finally, we proposed future research directions for optimizing EV extraction and developing targeted delivery systems. Through these efforts, we envision the seamless integration of plant‐derived EVs into mainstream medicine, offering safe and potent therapeutic alternatives across various medical disciplines.

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New opportunities and perspectives on biosynthesis and bioactivities of secondary metabolites from Aloe vera

Cited by 5 publications

References 287 publications

Applications of plant‐derived extracellular vesicles in medicine

Applications of plant‐derived extracellular vesicles in medicine

Production of bioactive phenolic compounds and cellulosic ethanol from Aloe vera residue

Polygala japonica Houtt.: A comprehensive review on its botany, traditional uses, phytochemistry, pharmacology, and pharmacokinetics

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