New opportunities for RGD-engineered metal nanoparticles in cancer

Abstract

The advent of nanotechnology has opened new possibilities for bioimaging. Metal nanoparticles (such as gold, silver, iron, copper, etc.) hold tremendous potential and offer enormous opportunities for imaging and diagnostics due to their broad optical characteristics, ease of manufacturing technique, and simple surface modification. The arginine-glycine-aspartate (RGD) peptide is a three-amino acid sequence that seems to have a considerably greater ability to adhere to integrin adhesion molecules that exclusively express on tumour cells. RGD peptides act as the efficient tailoring ligand with a variety of benefits including non-toxicity, greater precision, rapid clearance, etc. This review focuses on the possibility of non-invasive cancer imaging using metal nanoparticles with RGD assistance. Graphical abstract

Photodynamically Tumor Vessel Destruction Amplified Tumor Targeting of Nanoparticles for Efficient Chemotherapy

“…RGD-modified micelles (PPRMs) can target the integrin alphavbeta3 (αvβ3) which is highly expressed in the tumor neovascular endothelial cells and multiple tumors cells, such as breast cancer, lung cancer, and malignant melanoma cells. − Immortalized human umbilical vein endothelial cells (HUVEC) have high expression of αvβ3 integrin, which commonly used as an in vitro model of tumor neovascularization study . The quantitative cellular uptake of PPM and PPRM in the HUVEC at different time points was analyzed by flow cytometry.…”

Fe3O4 SPIONs in cancer theranostics—structure versus interactions with proteins and methods of their investigation

“…There are numerous examples of targeting moieties that can be used for this purpose: antibodies [70], aptamers [71], hyaluronic acid [72], folate [73], human serum proteins (albumin [74] and transferrin [75]) or various targeting peptides (e.g. H 7 K(R 2 ) 2 [76], ferritin [77], GE11 [78], RGD peptides [79]).…”

RGD peptide in cancer targeting: Benefits, challenges, solutions, and possible integrin–RGD interactions

“…[20][21][22][23] To target particular integrin receptors that are overexpressed in illnesses such as cancer, RGD peptides can be coupled to therapeutic molecules or nanoparticles. 5,[24][25][26][27] Integrins, notably αvβ3 and αvβ5, are elevated in malignant cells and vasculature. The medicine may be administered selectively to the tumor location by connecting RGD peptides to drug carriers, limiting the impact on normal cells and tissues.…”

“…To target particular integrin receptors that are overexpressed in illnesses such as cancer, RGD peptides can be coupled to therapeutic molecules or nanoparticles 5,24–27 . Integrins, notably αvβ3 and αvβ5, are elevated in malignant cells and vasculature.…”