New options in the treatment of respiratory syncytial virus disease

Mejías, Asunción; Ramilo, Octavio

doi:10.1016/j.jinf.2015.04.025

Cited by 39 publications

(28 citation statements)

References 64 publications

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“…Identification of the virus, as well as patients who are at a high risk of death, would help in prescribing antiviral therapies appropriately. Recent advances in the development of antiviral therapies for RSV are promising [50,51], ensuring more options for treating RSV infections in the near future. If an effective vaccine for RSV becomes available, it would be prudent to target high prevalent groups, such as nursing home residents.…”

Section: Discussionmentioning

confidence: 99%

Risk of mortality associated with respiratory syncytial virus and influenza infection in adults

et al. 2017

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BackgroundRespiratory syncytial virus (RSV) infection constitutes a substantial disease burden in the general population. However, the risk of death for RSV infection has been rarely evaluated with confounders or comorbidities adjusted. We aimed to evaluate whether RSV infection is associated with higher mortality than seasonal influenza after adjusting for confounders and comorbidities and the effect of oseltamivir on the mortality in patients with influenza infection.MethodsA retrospective cohort study was conducted on adult (≥18 years) patients admitted to the emergency department and ward of a university teaching hospital for suspected viral infection during 2013–2015 (N = 3743). RSV infection was diagnosed by multiplex PCR (N = 87). Adults hospitalized for seasonal influenza during the study period were enrolled as a comparison group (n = 312). The main outcome was 20-day all-cause mortality.We used Cox proportional hazard regression analyses to calculate the relative risk of death.ResultsAdult patients were less likely to be diagnosed with RSV than with influenza (2.3 vs 8.3%, respectively), were older and more likely to be diagnosed with pneumonia, chronic obstructive pulmonary disease, hypoxemia, and bacterial co-infection. In patients with RSV infection, the 20-day all-cause mortality was higher than that for influenza, (18.4 vs 6.7%, respectively). RSV infection showed significantly higher risk of death compared to the seasonal influenza group, with hazard ratio, 2.32 (95% CI, 1.17–4.58). Oseltamivir had no significant effect on mortality in patients with influenza.ConclusionsRSV infection was significantly associated with a higher risk of death than seasonal influenza, adjusted for potential confounders and comorbidities.

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Section: Discussionmentioning

confidence: 99%

Risk of mortality associated with respiratory syncytial virus and influenza infection in adults

et al. 2017

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“…Diagnosing RSV as the etiological factor enables the isolation of or cohorting the patients in order to reduce the spread of the infection and the implementation of the recommended management for severe obstruction [4,5]. Research is currently being conducted on the implementation of antiviral drugs which are more effective than the previously used ribavirine [23][24][25]. In the case of viral infections such as influenza, the establishment of the etiological factor enables the implementation of specific treatment.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Usefulness of Multiplex Real-Time PCR Tests in the Diagnostic and Therapeutic Process of Pneumonia in Hospitalized Children: A Single-Center Experience

Gowin

Bartkowska-Śniatkowska

Jończyk‐Potoczna

et al. 2017

BioMed Research International

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The aim of the study was assessment of the usefulness of multiplex real-time PCR tests in the diagnostic and therapeutic process in children hospitalized due to pneumonia and burdened with comorbidities. Methods. The study group included 97 children hospitalized due to pneumonia at the Karol Jonscher Teaching Hospital in Poznań, in whom multiplex real-time PCR tests (FTD respiratory pathogens 33; fast-track diagnostics) were used. Results. Positive test results of the test were achieved in 74 patients (76.3%). The average age in the group was 56 months. Viruses were detected in 61 samples (82% of all positive results); bacterial factors were found in 29 samples (39% of all positive results). The presence of comorbidities was established in 90 children (92.78%). On the basis of the obtained results, 5 groups of patients were established: viral etiology of infection, 34 patients; bacterial etiology, 7 patients; mixed etiology, 23 patients; pneumocystis, 9 patients; and no etiology diagnosed, 24 patients. Conclusions. Our analysis demonstrated that the participation of viruses in causing severe lung infections is significant in children with comorbidities. Multiplex real-time PCR tests proved to be more useful in establishing the etiology of pneumonia in hospitalized children than the traditional microbiological examinations.

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“…For both influenza A and B as well as A(H1N1), data from clinical trials suggest that early initiation of effective antiviral treatment reduces progression from upper respiratory tract infection (URTI) to lower respiratory tract infection (LRTI) to death [12]. This is also true for RSV infections, as antiviral or antibody treatment may be indicated in critical patients [13,14]. For other CRV, although no specific antiviral treatment is currently available [15], rapid diagnosis may assist prevention of further spread of infection.…”

Section: Discussionmentioning

confidence: 99%

Case Report on the Prevention of an Endemic Outbreak of Influenza B on an Allogeneic Transplant Ward

Heidrich

Boldt²,

Stölzel³

et al. 2016

J Leuk

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Respiratory tract infections pose a threat to hematopoietic stem cell recipients, increasing morbidity and mortality rates. To address this, preventive measures are of great importance. We describe the early detection of influenza B in a patient who received a recent hematopoietic transplantation, and elucidation of the transmission path using a point-of-care multiplex polymerase chain reaction panel, leading to prevention of viral spread. The use of risk-score systems and point-of-care testing should be further evaluated.

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New options in the treatment of respiratory syncytial virus disease

Cited by 39 publications

References 64 publications

Risk of mortality associated with respiratory syncytial virus and influenza infection in adults

Risk of mortality associated with respiratory syncytial virus and influenza infection in adults

Assessment of the Usefulness of Multiplex Real-Time PCR Tests in the Diagnostic and Therapeutic Process of Pneumonia in Hospitalized Children: A Single-Center Experience

Case Report on the Prevention of an Endemic Outbreak of Influenza B on an Allogeneic Transplant Ward

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