New oral liposomal vitamin C formulation: properties and bioavailability

Łukawski, Maciej; Dałek, Paulina; Borowik, Tomasz; Foryś, Aleksander; Langner, Marek; Witkiewicz, Wojciech; Przybyło, Magdalena

doi:10.1080/08982104.2019.1630642

Cited by 45 publications

(42 citation statements)

References 42 publications

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“…The ascorbate passive diffusion-based model provides a rationale for the higher sensitivity of cancer cells to the elevated ascorbate level in cell cultures and in vivo. The electric plasma membrane potential may play a role since in cancer cells it is significantly lower (from -5 mV to -20 mV) than that in normal cells (from -50 mV to -90 mV) [4,43,72]. Specifically, the ascorbate concentration gradient across the plasma membrane at steady state will be affected by active transport towards the cytoplasm, and passive diffusion in the opposite direction, which is enhanced by the negative inside membrane electric potential.…”

Section: Ascorbate Homeostasis Inside the Cellmentioning

confidence: 99%

“…Later it was observed that ascorbate at high concentrations (above 1 mM) is toxic to cancer cells, revealing the complex nature of ascorbate functions. The importance of ascorbate homeostasis has been further strengthened by the discovery that there are two dedicated ascorbate transporters, namely SVCT1 and SVCT2, encoded in genes SLC23A1 and SLC23A2 [4,5]. The two discoveries shed a new light on the essential role of ascorbate in cellular processes, other than being simply one of many antioxidants [2].…”

Section: Introductionmentioning

confidence: 99%

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On the physiological and cellular homeostasis of ascorbate

Przybyło

Langner

2020

Cell Mol Biol Lett

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Recent interest in the role of ascorbate in crucial metabolic processes is driven by the growing number of medical reports that show beneficial effects of ascorbate supplementation for maintaining general well-being and recovery from a variety of medical conditions. The effect of ascorbate on the local body environment highly depends on its local concentration; at low concentrations it can cause the reduction of reactive oxygen and facilitate activities of enzymes, while at high concentrations it generates free radicals by reducing ferric ions. Ascorbate serving as an electron donor assists the iron-containing proteins and the iron transfer between various aqueous compartments. These functions require effective and adjustable mechanisms responsible for ascorbate biodistribution. In the paper we propose a new biophysical model of ascorbate redistribution between various aqueous body compartments. It combines recent experimental evidence regarding the ability of ascorbate to cross the lipid bilayer by unassisted diffusion, with active transport by well-characterized sodium vitamin C transporter (SVCT) membrane proteins. In the model, the intracellular concentration of ascorbate is maintained by the balance of two opposing fluxes: fast active and slow passive transport. The model provides a mechanistic understanding of ascorbate flux across the epidermal barrier in the gut as well as the role of astrocytes in ascorbate recycling in the brain. In addition, ascorbate passive diffusion across biological membranes, which depends on membrane electric potentials and pH gradients, provides the rationale for the correlation between ascorbate distribution and the transfer of iron ions inside a cell. The proposed approach provides, for the first time, a mechanistic account of processes leading to ascorbate physiological and cellular distribution, which helps to explain numerous experimental and clinical observations.

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Section: Ascorbate Homeostasis Inside the Cellmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

On the physiological and cellular homeostasis of ascorbate

Przybyło

Langner

2020

Cell Mol Biol Lett

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“…Oral liposomal vitamin C formulations have been developed to improve its stability and enhance its bioavailability (Caritá et al 2020;Davis et al 2016;Łukawski et al 2019).…”

Section: Marketed Productsmentioning

confidence: 99%

Plant Kingdom as Source of Vitamins

Hennebelle¹

2020

Handbook of Dietary Phytochemicals

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A vitamin is an organic substance necessary, in small quantities, for the correct functioning of the metabolism of a living organism. It is an essential nutrient because this substance cannot be synthesized in sufficient quantity by this organism and thus must be provided through the food intake. Each organism has specific needs: a molecule can be a vitamin for one species and not be it for another. It is the case for example of Vitamin C. Some vitamins are water-soluble compounds, including all vitamin Bs (B1, B2, B3, B5, B6, B7, B9, B12) and vitamin C. Others are fat-soluble compounds and encompass vitamins A, D, E, and K. In this chapter, we have chosen to provide an overview of recent literature data only about vitamins provided exclusively or significantly by plant food, in particular vitamins A (as provitaminic carotenoids), B1, B9, C, E, and K1. Vitamins provided by animal food, such as vitamin D or vitamin B12, will be not discussed in this chapter.

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“…Vitamin C plasma concentration can be increased by oral application of liposomes. Lipid aggregates can prevent vitamin C degradation in the gastrointestinal tract [29][30][31][32]. Davis et al showed that the oral application of 4 g of vitamin C encapsulated in liposomes increased the plasma concentration up to C max (about 200 µM) after 3 hours [33].…”

Section: Introductionmentioning

confidence: 99%

“…Davis et al showed that the oral application of 4 g of vitamin C encapsulated in liposomes increased the plasma concentration up to C max (about 200 µM) after 3 hours [33]. Liposomes composed of phosphatidylcholines are an important component of a balanced diet [32]. Despite cholines and phosphatidylcholines being crucial for a wide range of physiological functions, most of the population's consumption remains far below the recommendations [34].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Resorption of Liposomal Packed Vitamin C Monitored by Ultrasound

Prantl

Eigenberger

Gehmert

et al. 2020

JCM

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Vitamin C is an essential nutrient for humans and is involved in a plethora of health-related functions. Several studies have shown a connection between vitamin C intake and an improved resistance to infections that involves the immune system. However, the body cannot store vitamin C and both the elevated oral intake, and the intravenous application have certain disadvantages. In this study, we wanted to show a new formulation for the liposomal packaging of vitamin C. Using freeze etching electron microscopy, we show the formed liposomes. With a novel approach of post-processing procedures of real-time sonography that combines enhancement effects by contrast-like ultrasound with a transducer, we wanted to demonstrate the elevated intestinal vitamin C resorption on four participants. With the method presented in this study, it is possible to make use of the liposomal packaging of vitamin C with simple household materials and equipment for intake elevation. For the first time, we show the enhanced resorption of ingested liposomes using microbubble enhanced ultrasound imaging.

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New oral liposomal vitamin C formulation: properties and bioavailability

Cited by 45 publications

References 42 publications

On the physiological and cellular homeostasis of ascorbate

On the physiological and cellular homeostasis of ascorbate

Plant Kingdom as Source of Vitamins

Enhanced Resorption of Liposomal Packed Vitamin C Monitored by Ultrasound

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