New Paper-based Microfluidic Analytical Devices for Kojic Acid Assay Based on Double-sided Adhesive Tape

Abstract

Kojic acid is an antioxidant used by the cosmetics industry but the excessive usage of kojic acid may cause harm to human health. Therefore, it is important to detect the content of kojic acid in cosmetic products. In this work, the low-cost and simple paper-based analytical devices (μPADs) based on double-sided adhesive tape were developed for the colorimetric detection of kojic acid. The μPADs were fabricated by dissolving double-sided adhesive tape in toluene and then making the patterned adhesive tape penetrate into the filer paper. Ferric nitrate was used as the reagent to react with kojic acid, and the product of their chelating reaction caused the color change from colorless to orange-red. The ImageJ software was used to analyze the color intensity and the corresponding correction curve was determined. The μPADs for the detection of kojic acid exhibited a wide linear range (0.05 - 4 mM) and the detectable limit was 0.05 mM. The good selectivity and reproducibility were also demonstrated.

Ratiometric electrochemical detection of kojic acid based on glassy carbon modified MXene nanocomposite

“…This underscores the vital role of KA sensing as a far-reaching research domain. A variety of sensing techniques, including fluorescence-based, 10 spectrophotometry, 11 electrochemistry, 12 high-performance liquid chromatography, 13 and mass spectrometry, 14 have been documented for KA determination in food and cosmetic items. Of these, electrochemical methods exhibit high sensitivity, selectivity, cost-effectiveness, and user-friendliness, positioning them as a promising and favoured choice.…”