New paradigms in the conservative surgical and interventional management of adenomyosis

Alvi, F.A.; Glaser, L.M.; Chaudhari, A.; Tsai, Susan; Milad, Magdy P.

doi:10.1097/gco.0000000000000371

Cited by 18 publications

(14 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Approximately 35% of females with adenomyosis are asymptomatic and the diagnosis is based on routine gynecological transvaginal ultrasound; MRI contributes decisively to the diagnosis. For the differential diagnosis and staging of the disease, MRI is clearly the examination of choice due to its sensitivity (88-93%) and specificity (66-91%) (12,26,(28)(29)(30). However, clinical diagnosis of adenomyosis is only hypothetical and the disease is definitively diagnosed based on histological examination following hysterectomy (12,26,(28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

Significance of changes in inflammatory parameters following uterine artery embolization in pre‑menopausal females

et al. 2020

View full text Add to dashboard Cite

The purpose of the present study was to describe the course of changes in laboratory inflammatory markers following bilateral uterine artery embolization (UAE) as a treatment for leiomyomas and adenomyosis. The body temperature was measured and blood samples were collected to determine white blood cell (WBC) count and C-reactive protein (CRP) levels in 270 patients on the day prior to UAE and for up to 4 days post-embolization. Aside from a single case with a non-inflammatory complication, none of the other cases had any complications. Post-UAE leukocytosis with a mean maximum value of 10.8±3.5x10 9 /l (range, 5.9-18.6x10 9 /l) was observed one-year post-intervention. The mean leukocyte numbers were indicated to be higher on day 3 post-UAE. The CRP level was also increased post-UAE, with a mean maximum value of 7.75±3.5 mg/dl. Maximum levels were reached in 8 patients on the 2nd and in 11 patients on the 3rd post-operative day. The maximum pain score was ~5.5 and reached its lowest level at the end of the 12th week post-intervention. The present study did not consider an association between the embolic material used or uterus size with the level of treatment success. No complications were observed post-UAE; however, a significant increase in the WBC count was observed within the first 3 days, indicating mild leukocytosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Significance of changes in inflammatory parameters following uterine artery embolization in pre‑menopausal females

et al. 2020

View full text Add to dashboard Cite

show abstract

“…LNG‐IUD, GnRH agonists, danazol, oral progestins and aromatase inhibitors have all been effective in treating adenomyosis related symptoms . Surgical treatment includes fertility‐sparing surgeries such as excision or cytoreductive procedures, and non‐fertility sparing procedures such as endometrial ablation, uterine artery embolization or hysterectomy …”

Section: Diagnosis and Managementmentioning

confidence: 99%

“…[31][32][33] Surgical treatment includes fertility-sparing surgeries such as excision or cytoreductive procedures, and non-fertility sparing procedures such as endometrial ablation, uterine artery embolization or hysterectomy. 34…”

Section: Diagnosis and Management Endometriosis And Adenomyosismentioning

confidence: 99%

Gynecological associated disorders and management

et al. 2019

View full text Add to dashboard Cite

Background Chronic pelvic pain syndrome is complex and involves multiple organ systems. The gynecological aspects of chronic pelvic pain syndrome can be divided into four different areas: intra‐abdominal, vaginal, pelvic floor muscles and sexual pain. This article provides an overview of gynecological evaluation in patients with chronic pelvic pain and reviews the most common gynecological diagnoses and their management. Methods An extensive review of the literature including guidelines from the International Continence Society, the European Association of Urology, and the International Association for the Study of Pain was performed. Results Gynecological evaluation of patients with chronic pelvic pain begins with a thorough history and physical examination. Laboratory tests, imaging studies and diagnostic procedures can be used as adjuncts to make a diagnosis. Treatment modalities include physical therapy, medications, trigger points injections, and surgery. Conclusion Common gynecological diagnoses of chronic pelvic pain include endometriosis, adenomyosis, vulvodynia, high tone pelvic floor dysfunction, and genitopelvic pain/penetration disorder. Gynecology is one of the many systems that can be associated with chronic pelvic pain. Managing patients with chronic pelvic pain requires a multimodal and multidisciplinary approach.

show abstract

“…Currently, several minimally invasive treatments are used to treat adenomyosis in clinical practice. However, all of these treatment options have limitations, such as adverse events, insufficient efficacy or a high recurrence rate [2]. Among the various options, hysterectomy remains the 'gold standard' treatment for adenomyosis, especially for severe adenomyosis [3].…”

mentioning

confidence: 99%

Ultrasound-guided transvaginal radiofrequency ablation combined with levonorgestrel-releasing intrauterine system for symptomatic uterine adenomyosis treatment

Nie

Hou

Guo

2021

International Journal of Hyperthermia

View full text Add to dashboard Cite

Objective: To evaluate the clinical outcomes of transvaginal ultrasound-guided radiofrequency ablation (RFA) combined with a levonorgestrel-releasing intrauterine system (LNG-IUS) for the treatment of symptomatic uterine adenomyosis. Methods: Patients with symptomatic uterine adenomyosis treated with ultrasound-guided RFA in combined with an LNG-IUS from January 2013 to January 2016 and followed up for 3 years after treatment were selected. Assessment endpoints included the uterine volume reduction rate, dysmenorrheal score, symptom severity score and adverse events. Results: Among the 72 patients, 64 completed the 3-year follow-up evaluations after treatment. No LNG-IUS expulsion was reported. Dysmenorrhea and symptom severity scores statistically significantly declined after the combined treatment of RFA and LNG-IUS was administered. The uterine volume significantly decreased, and the average reduction rate was 55%. Conclusion: Ultrasound-guided RFA combined with an LNG-IUS might be a simple, safe and effective alternative for the treatment of symptomatic adenomyosis.

show abstract

New paradigms in the conservative surgical and interventional management of adenomyosis

Abstract: A multitude of surgical and interventional options are available for young women with symptomatic adenomyosis. These treatment methods have unique associated risks and benefits, and may have varying impacts on long-term symptom control, fertility, and reproductive outcomes.

Cited by 18 publications

References 68 publications

Significance of changes in inflammatory parameters following uterine artery embolization in pre‑menopausal females

Significance of changes in inflammatory parameters following uterine artery embolization in pre‑menopausal females

Gynecological associated disorders and management

Ultrasound-guided transvaginal radiofrequency ablation combined with levonorgestrel-releasing intrauterine system for symptomatic uterine adenomyosis treatment

Contact Info

Product

Resources

About