New paraneoplastic syndrome in chronic basophilic leukemia

Cehreli, Cavit; Ateş, Halil; Cehreli, Ruksan; Sercan, Zeynep; Demırkan, Fatih

doi:10.1007/s12185-013-1281-4

Cited by 4 publications

(31 citation statements)

References 15 publications

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“…CBL is a very rare type of leukemia, because seven patients with CBL appeared in the literature [4–7]. The two of the four cases reported as CBL by Pardanani et al [4] could be categorized as SM-CBL according to the WHO major morphologic diagnostic criteria [3] as in the case described by Lahortiga et al [5].…”

Section: Discussionmentioning

confidence: 99%

“…A 73 year old Turkish female patient who presented with weakness, epigastric fullness and decreased appetite had a prolonged duration of hematologic remission by the treatment of her CBL with hydroxyurea (HU) [7]. At presentation , complete blood counts (CBC) showed marked decrease in hemoglobin.…”

Section: Case Presentationmentioning

confidence: 99%

“…Her white blood cell (wbc) count except for the basophilia and eosinophilia was normal. The patient has been watched without treatment to see the recurrence of febrile episodes [7]. …”

Section: Case Presentationmentioning

confidence: 99%

“…CBL is an extremely rare type of leukemia with the appearance of seven cases in the literature [4–7]. Four of the seven patients reported by Pardanani et al identified by screening of electronic data base in Mayo Clinic [4] MCL, occuring as a second neoplasia in association with undefined MC morphology and de novo CBL relapse have not been described in the World’s literature [4–7].…”

Section: Introductionmentioning

confidence: 99%

“…Four of the seven patients reported by Pardanani et al identified by screening of electronic data base in Mayo Clinic [4] MCL, occuring as a second neoplasia in association with undefined MC morphology and de novo CBL relapse have not been described in the World’s literature [4–7]. A case of MCL occuring as a second neoplasia in association with undefined MC morphology, increase in IL-6 levels and accelerated phase of de novo CBL was described.…”

Section: Introductionmentioning

confidence: 99%

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Mast cell leukemia associated with undefined morphology and chronic basophilic leukemia

et al. 2014

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BackgroundMast cell leukemia (MCL) is rare type of neoplasia with an incidence of 1% in a large series of 342 adult patients with systemic mastocytosis (SM). Chronic basophilic leukemia (CBL) is an extremely rare type of leukemia with appearance of 7 cases in the literature.Case presentationA 73 year-old female patient who presented with weaknes, had a prolonged duration of hematologic remission after treatment of her CBL by hydroxyurea (HU). Evolution of SM occurring as a second neoplasia concurrently with relapse of de novo CBL was demonstrated by mast cells (MCs) infiltration in the bone marrow (BM) biopsy and smear and increase in tryptase level. Transformation to MCL with simultaneous occurrance of accelerated phase of CBL were documented by the appearance of MCs in both BM and peripheral blood (PB) smears, antigen expressions detected by flow cytometry and spesific stains. Sequence analysis of c-kit gene revealed c-kit exon 11 K550N mutation. Undefined associations of MCL with different mast cell morphology, increase in IL-6 level and accelerated phase of de novo CBL was described.ConclusionElevations in CRP and IL-6 levels occurring with increases in basophil counts to high levels revealed that febrile episodes with abdominal pain seen in our patient were induced by increase in IL-6 levels released from neoplastic basophils. Neoplastic basophils with diffuse and coarse basophilic granules possibly mimic neutrophils with toxic granules and cause wrong characterization of neoplastic basophils as neutrophils by the automated blood cell counters and misleaded physicians.

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Section: Discussionmentioning

confidence: 99%

Section: Case Presentationmentioning

confidence: 99%

“…Her white blood cell (wbc) count except for the basophilia and eosinophilia was normal. The patient has been watched without treatment to see the recurrence of febrile episodes [7]. …”

Section: Case Presentationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mast cell leukemia associated with undefined morphology and chronic basophilic leukemia

et al. 2014

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A review of current knowledge of myeloproliferative disorders in the horse

2021

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Myeloid disorders are conditions being characterized by abnormal proliferation and development of myeloid lineage including granulocytes (neutrophils, eosinophils and basophils), monocytes, erythroids, and megakaryocytes precursor cells. Myeloid leukemia, based on clinical presentation and proliferative rate of neoplastic cells, is divided into acute (AML) and myeloproliferative neoplasms (MPN). The most commonly myeloid leukemia reported in horses are AML-M4 (myelomonocytic) and AML-M5 (monocytic). Isolated cases of AML-M6B (acute erythroid leukemia), and chronic granulocytic leukemia have also been reported. Additionally, bone marrow disorders with dysplastic alterations and ineffective hematopoiesis affecting single or multiple cell lineages or myelodysplastic diseases (MDS), have also been reported in horses. MDSs have increased myeloblasts numbers in blood or bone marrow, although less than 20%, which is the minimum level required for diagnosis of AML. This review performed a detailed description of the current state of knowlegde of the myeloproliferative disorders in horses following the criteria established by the World Health Organization.

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Basophils Unchained: A Rare Form of Leukemia

haes¹,

Corveleyn²,

Schots³

et al. 2021

annhematoloncol

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Primary Chronic Basophilic Leukemia (CBL) is an extremely rare disease and thus knowledge of this disease remains limited. There are no universal diagnostic criteria nor has the underlying pathogenetic mechanism been elucidated. In this peculiar case, we present a 93-year-old woman with an acute symptomatology of fatigue compounded by a manifest leukocytosis with 43% basophils in peripheral blood. The bone marrow aspirate also showed basophilia, 56% specifically. Interestingly, Next Generation Sequencing (NGS) on the bone marrow sample revealed three possible driver mutations, namely in the IDH2, DNMT3A, and BCOR gene. To date, NGS has never been performed on samples of patients with primary CBL. Our findings could be of great value in the search for the pathogenetic mechanism of this rare disease and to help find a successful treatment. Our patient was palliated with hydroxyurea to lower the white blood cells. Initially, this had a good effect, but unfortunately, she died two months after the diagnosis.

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New paraneoplastic syndrome in chronic basophilic leukemia

Cited by 4 publications

References 15 publications

Mast cell leukemia associated with undefined morphology and chronic basophilic leukemia

Mast cell leukemia associated with undefined morphology and chronic basophilic leukemia

A review of current knowledge of myeloproliferative disorders in the horse

Basophils Unchained: A Rare Form of Leukemia

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