New patterns of menstrual disorders’ treatment – unification of the method

Purpose of the study: a comparative analysis of the hormonal profile in patients with menstrual disorders on the background of hyperprolactinemia during puberty after different treatments.Materials and methods. 94 adolescent girls with formation of menstrual function were examined. The mean age of patients was 14.0 ± 1.5 years. Participants were divided into groups according to the management: I (main) group – girls with menstrual disorders on the background of hyperprolactinemia during puberty, who received differentiated approach proposed by study authors (n = 33); II (comparison) group – girls with menstrual disorders on the background of hyperprolactinemia during puberty, who received conventional treatment (n = 31); III (control) group – healthy girls in puberty (n = 30).A high-calorie, balanced, protein-enhanced diet and psychotherapy for girls with severe weight loss; a high-calorie, balanced, protein-enhanced diet for girls with insufficient body weight; physical training for girls with normal weight and overweight was recommended. A comprehensive anti-stress therapy for high levels of personal and situational anxiety was recommended. The drug with a mild dopaminergic effect Cyclodynon® to correct prolactin levels and normalize menstrual function in adolescent girls was used.Results. The obtained data indicate a decrease in ovarian reserve in girls with menstrual disorders on the background of hyperprolactinemia from adolescence age. Dynamics of prolactin reduction in girls with hyper- and hypomenstrual syndromes and amenorrhea in group I was faster compared to group II as a result of treatment. Prolactin level in patients with hypermenstrual syndrome as early as 3 months after the start of therapy did not differ from its level in healthy girls; in patients with hypomenstrual syndrome and amenorrhea – after 6 months. Therapeutic effect persisted throughout the first year of observation.Conclusions. A differentiated approach to the management of patients with menstrual disorders on the background of hyperprolactinemia during puberty was found to be twice as effective as in conventional measures.

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Hypomenstrual syndrome in adolescent girls as a result of reproductive dysfunction in their mothers

Artyomenko

Nastradina

Nitochko

et al. 2021

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In recent years in Ukraine and in the world there has been a clear tendency towards deterioration in the indicators of the somatic health of children and adolescents, that is negatively affects the processes of reproductive health formation and it state in the future. Concern for adolescent girl's health, including their reproductive system, forms an enormous contribution to the society future. That's why big attention is paid to the formation and saving reproductive health of adolescent girls. The period of sexual development is defining in a woman's life and is considered a key moment on the path of reproductive maturity. Today it has been established that the reproductive health formation is influenced by environmental, socio-economic factors and the presence of somatic diseases. Despite the fact that the pathogenetic mechanisms of the reproductive system formation are extremely complex and sensitive to the effects of negative factors, the appearance of destructive factors at this time can disrupt the physiological chain of functioning of the hormonal mechanisms which regulate the reproductive system. Disorders of the menstrual cycle is one of the most common pathological conditions, combining pathogenetically different diseases, which are manifested by a violation of the menstrual duration and frequency, amount of menstrual flow. According to domestic literature, hypomenstrual syndrome (oligomenorrhea, amenorrhea) is in the first place among menstrual dysfunctions in adolescent girls in the structure of gynecological morbidity and is up to 45%. Menstrual irregularities that occur during adolescence often persist into the future, causing infertility, obstetric pathology, perinatal loss and other reproductive health problems during childbearing years. The problem of the menstrual cycle formation has been little studied, but it is socially significant, very relevant and requires further study.Thus, girls with menstrual disorders constitute a group of increased risk of gynecological diseases in women of reproductive age, since many chronic diseases of adults are a protracted pathology of adolescents. Therefore, adolescent girls should be examined and treated by a specialist in pediatric and adolescent gynecology, pediatric endocrinologist, pediatrician and family doctor.

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New patterns of menstrual disorders’ treatment – unification of the method

Cited by 5 publications

References 16 publications

Pathogenetic substantiation of advantages and duration of phytoselective therapy of the menstrual cycle disorders

Pathogenetic substantiation of advantages and duration of phytoselective therapy of the menstrual cycle disorders

Comparative analysis of modern approaches to the correction of hyperprolactinemia in adolescent girls with menstrual dysfunction

Hypomenstrual syndrome in adolescent girls as a result of reproductive dysfunction in their mothers

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