2021
DOI: 10.36371/port.2021.6
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New Perceptions in the Cardioprotective Effect of Metformin Against Isoproterenol Induced Cardiotoxicity in Male Rats

Abstract: Background and objective: Recent clinical trials have shown that metformin improves clinical cardiovascular outcome in type-2 diabetic patients independently of its insulin-sensitizing effect. This study was sought to evaluate the potential cardioprotective effects of metformin on isoproterenol-induced cardiac stress in diabetic and non-diabetic rats. Materials and Methods: Diabetes was induced by using streptozocin (60 mg/kg, i.p.) while non-diabetic rats received saline. Rats in both experimental groups were… Show more

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