2023
DOI: 10.3390/nu15041030
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New Perspective on Anorexia Nervosa: Tryptophan-Kynurenine Pathway Hypothesis

Abstract: Anorexia nervosa (AN), affecting up to 4% of all females and 0.3% of all males globally, remains the neuropsychiatric disorder with the highest mortality rate. However, the response to the current therapeutic options is rarely satisfactory. Considering the devastating prognosis of survival among patients with AN, further research aimed at developing novel, more effective therapies for AN is essential. Brain and serum tryptophan is mostly converted along the kynurenine pathway into multiple neuroactive derivati… Show more

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