New perspectives of improvement of compliance - results of open study of adherence of patients to treatment with fixed in one blister combinations of enalapril and indapamide

Abstract

The aim of the study was to evaluate the adherence of patients to treatment with new fixed in one blister combinations of enalapril and indapamide. 115 patients participated in the study. In conclusion, analysis revealed high efficacy of studied combinations, which can be partly explained by high compliance of patients.

Adherence to antihypertensive medication in Russia: a scoping review of studies on levels, determinants and intervention strategies published between 2000 and 2017

“…The findings of studies of the association between adherence and grade of HT, experience of hypertensive crisis, and duration of HT were not consistent [27, 29, 33, 38–41].…”

“…Adherence was assessed using data from cross-sectional surveys and from baseline data in prospective observational intervention studies. In studies using the MMAS-4 [11–19, 21, 23–27, 30, 33] adherence to AHT varied from 1.62 ± 0.27 [11] to 3.12 ± 0.86 points [35] out of a maximum of four (Additional file 3). Among these studies, the highest rates of adherence were found in post-marketing studies, all with large sample sizes.…”

“…12 studies examined associations between adherence and various socio-demographic, clinical and other variables (access to the MAS, home BP monitoring, frequency of visits to a doctor, etc.). Higher adherence was associated with female gender [29, 33, 35, 38, 41], age over 50 years [29, 33], not living alone [29, 38], employment [27, 33], higher education [33], and living in a city [41] (Additional file 4).…”

“…Interventions to increase adherence were mainly either patient education (in various forms) in 6 studies [12, 13, 19–23] or optimization of the drug administration regimen in 11 studies [11–13, 15–19, 32, 33, 35, 36], among which 9 used a fixed-dose combination of drugs [11, 15, 16, 18, 19, 32, 33, 35, 36]. One study gave patients an electronic version of the SCORE scale, with the physician showing the patient how their risk would be reduced if they stopped smoking, controlled their BP and reduced their cholesterol [14].…”

“…Recruitment process not describedRandomized non-blinded controlled intervention study60Intervention group: 62 ± 9.4, control group: 63 ± 8.91–2(a) complex intervention on adherence;(b) small sample size, relatively short follow up period – 3 mthVologdina et al [32]2009Not statedMen and women with IHD and grades 1–2 of HT. Recruitment process not describedRandomized non-blinded controlled by closed envelope method7080.7 ± 2.7 (female)/80.3 ± 2.5 (male)1–2(a) studying adherence in the elderly;(b) small sample size, relatively short follow up period – 3 mthSviryaev et al [33]2006Ambulatory care facilityMen or women older than 18, with grades 1–2 of HT with irregular therapyProspective observational intervention study11551.3 ± 9.61–2(a) follow up period 6 mth;(b) no control group, numerical indicators of adherence level aren’t presented in the publicationMorozov et al [34]2010The authors are affiliation at Russian military medical Academy, St. PetersburgPatients with grades 1–2 of HTCross-sectional8630–73 y (54 ± 4,8)1–2(b) only possible to extract baseline data, non-standard way of MMAS-4 analyzeKotovskaya et al [35]2015Patients attending 830 physicians in 113 citiesMen or women older than 18, with uncontrolled HT taking ACE inhibitors or angiotensin receptor blockersProspective observational intervention study243559.3 ± 11.2Uncontrolled HT b (a) big sample size, multicenter;(b) MMAS modified with 2 additional questions, no control group, relatively short follow up period – 3 mthPanov et al [36]2015Federal Medical Research Center, St. PetersburgPatients with grades 1–2 of HT and IHDProspective observational intervention study6057.65 ± 1.591–2(a) follow up period - 12 mth;(b) small sample sizeOschepkova et al [37]2004Patients who visited outpatient department of the Russian Cardiology Scientific and Production CenterMen and women aged 30–71, with grades 1–2 of HT, without MI, stroke, heart failure, heart arrhythmias. Recruitment process not describedRandomized non-blinded controlled intervention study3054 ± 111–2(a) home BP devices as a way to increase adherence;(b) described as randomized but main group – 19 ppl, control group − 11, small sample sizeKontsevaya et al [38, 39]2015Patients who visited Outpatient Cardiology Clinic…”