New perspectives on the basal forebrain cholinergic system in Alzheimer’s disease

Berry, Anne S.; Harrison, Theresa M.

doi:10.1016/j.neubiorev.2023.105192

Cited by 23 publications

(5 citation statements)

References 199 publications

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“…Given the essential role of cholinergic system in regulation of cognitive functions 16 – 19 , we crossed the ChAT-Cre mice with Hrh1 fl/fl mice to induce Hrh1 (the H 1 R gene) deletion in cholinergic neurons. In a previous study, we have shown that the ChAT-Cre;Hrh1 fl/fl mice exhibited similar functional capacity for olfactory function, motor coordination, body growth rate, body temperature, pain sensitivity, and normal locomotor activity when compared with littermates 15 .…”

Section: Resultsmentioning

confidence: 99%

Histamine H1 receptors in dentate gyrus-projecting cholinergic neurons of the medial septum suppress contextual fear retrieval in mice

Cheng,

Xiao,

Lin

et al. 2024

Nat Commun

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Fear memory is essential for survival and adaptation, yet excessive fear memories can lead to emotional disabilities and mental disorders. Despite previous researches have indicated that histamine H1 receptor (H1R) exerts critical and intricate effects on fear memory, the role of H1R is still not clarified. Here, we show that deletion of H1R gene in medial septum (MS) but not other cholinergic neurons selectively enhances contextual fear memory without affecting cued memory by differentially activating the dentate gyrus (DG) neurons in mice. H1R in cholinergic neurons mediates the contextual fear retrieval rather than consolidation by decreasing acetylcholine release pattern in DG. Furthermore, selective knockdown of H1R in the MS is sufficient to enhance contextual fear memory by manipulating the retrieval-induced neurons in DG. Our results suggest that H1R in MS cholinergic neurons is critical for contextual fear retrieval, and could be a potential therapeutic target for individuals with fear-related disorders.

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Section: Resultsmentioning

confidence: 99%

Histamine H1 receptors in dentate gyrus-projecting cholinergic neurons of the medial septum suppress contextual fear retrieval in mice

Cheng,

Xiao,

Lin

et al. 2024

Nat Commun

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“…Previous studies have illustrated the relationship between cholinergic neuron degeneration and cognitive dysfunction in dementia patients ( Berry and Harrison, 2023 ), thus proposing the classical “cholinergic hypothesis”( Hampel et al, 2018 ). Recently, studies reported enlightening findings on the cholinergic system in AD treatment.…”

Section: Influence Of Different Neuronal and Glial Systems On Movemen...mentioning

confidence: 99%

The mechanistic effects of acupuncture in rodent neurodegenerative disease models: a literature review

Li,

Deng,

Jiang

et al. 2024

Front. Neurosci.

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Neurodegenerative diseases refer to a battery of medical conditions that affect the survival and function of neurons in the brain, which are mainly presented with progressive loss of cognitive and/or motor function. Acupuncture showed benign effects in improving neurological deficits, especially on movement and cognitive function impairment. Here, we reviewed the therapeutic mechanisms of acupuncture at the neural circuit level in movement and cognition disorders, summarizing the influence of acupuncture in the dopaminergic system, glutamatergic system, γ-amino butyric acid-ergic (GABAergic) system, serotonergic system, cholinergic system, and glial cells at the circuit and synaptic levels. These findings can provide targets for clinical treatment and perspectives for further studies.

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“…Yet, treatment with Cistanche deserticola polysaccharides restored valine, L-methionine, uric acid and proline levels in serum, alleviated an amino acid imbalance, and enhanced cognitive function in D-galactose-induced AD mice (37). Furthermore, cholinergic metabolism, crucial for regulating neurotransmission, memory, and muscle movement, might also contribute to AD-related cognitive decline, possibly linked to abnormal cholinergic neuron count and function (59). Encouragingly, Angelica sinensis polysaccharides exhibited promise in reducing acetylcholinesterase (AChE) levels, elevating acetylcholine (ACh) and choline acetyltransferase (ChAT) levels, and improving memory impairment in AD rats through the BDNF/CREB pathway (43).…”

Section: Dietary Polysaccharides and The Interventions For Alzheimer'...mentioning

confidence: 99%

Unveiling the neuroprotective potential of dietary polysaccharides: a systematic review

Guo,

Pang,

Zhao

et al. 2023

Front. Nutr.

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Central nervous system (CNS) disorders present a growing and costly global health challenge, accounting for over 11% of the diseases burden in high-income countries. Despite current treatments, patients often experience persistent symptoms that significantly affect their quality of life. Dietary polysaccharides have garnered attention for their potential as interventions for CNS disorders due to their diverse mechanisms of action, including antioxidant, anti-inflammatory, and neuroprotective effects. Through an analysis of research articles published between January 5, 2013 and August 30, 2023, encompassing the intervention effects of dietary polysaccharides on Alzheimer’s disease, Parkinson’s disease, depression, anxiety disorders, autism spectrum disorder, epilepsy, and stroke, we have conducted a comprehensive review with the aim of elucidating the role and mechanisms of dietary polysaccharides in various CNS diseases, spanning neurodegenerative, psychiatric, neurodevelopmental disorders, and neurological dysfunctions. At least four categories of mechanistic bases are included in the dietary polysaccharides’ intervention against CNS disease, which involves oxidative stress reduction, neuronal production, metabolic regulation, and gut barrier integrity. Notably, the ability of dietary polysaccharides to resist oxidation and modulate gut microbiota not only helps to curb the development of these diseases at an early stage, but also holds promise for the development of novel therapeutic agents for CNS diseases. In conclusion, this comprehensive review strives to advance therapeutic strategies for CNS disorders by elucidating the potential of dietary polysaccharides and advocating interdisciplinary collaboration to propel further research in this realm.

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New perspectives on the basal forebrain cholinergic system in Alzheimer’s disease

Cited by 23 publications

References 199 publications

Histamine H1 receptors in dentate gyrus-projecting cholinergic neurons of the medial septum suppress contextual fear retrieval in mice

Histamine H1 receptors in dentate gyrus-projecting cholinergic neurons of the medial septum suppress contextual fear retrieval in mice

The mechanistic effects of acupuncture in rodent neurodegenerative disease models: a literature review

Unveiling the neuroprotective potential of dietary polysaccharides: a systematic review

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