New perspectives on the modification of silica aerogel particles with ionic liquid used in lipase immobilization with platform in ethyl esters production

Lisboa, Milena Chagas; Rodrigues, Clóvis Antônio; Barbosa, Anderson; Mattedi, Silvana; Freitas, Lisiane Santos; Mendes, Adriano A.; Dariva, Cláudio; Franceschi, Elton; Lima, A. S.; Soares, Cleide Mara Faria

doi:10.1016/j.procbio.2018.09.015

Cited by 19 publications

(15 citation statements)

References 43 publications

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“…Lipase biotransformations have significant application, and this is reflected in the ionic liquid field by a substantial literature (Itoh et al, 2002; Zhao et al, 2010a, 2018; Latif et al, 2014; Kim et al, 2016; Carvalho et al, 2018; Itoh, 2018; Lisboa et al, 2018; Park et al, 2018; Zhong et al, 2018). As such, lipase-catalyzed biotransformations have been the topic of recent reviews, covering enantioselective transesterification, biofuel production and polymer synthesis in ionic liquids (Itoh, 2017a; Elgharbawy et al, 2018), and ionic liquid-mediated activation of lipase-catalyzed reactions (Itoh, 2018).…”

Section: Enzymesmentioning

confidence: 99%

“…The immobilization of Burkholderia cepacia lipase onto silica xerogel with protic ionic liquid ( N -methylmonoethanolamine pentanoate) and in-depth characterization of the activity and operational stability could afford appropriate catalysts for such a circulating reactor (Carvalho et al, 2018). Experimental data of the physical adsorption of B. cepacia lipase on an aerogel-ionic liquid system based on [N 1, 1, 1, 18 ][NTf 2 ], with an isotherm model fitted to the data, provides an alternative, characterized immobilization system (Lisboa et al, 2018).…”

Section: Enzymesmentioning

confidence: 99%

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Proteins in Ionic Liquids: Reactions, Applications, and Futures

et al. 2019

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Biopolymer processing and handling is greatly facilitated by the use of ionic liquids, given the increased solubility, and in some cases, structural stability imparted to these molecules. Focussing on proteins, we highlight here not just the key drivers behind protein-ionic liquid interactions that facilitate these functionalities, but address relevant current and potential applications of protein-ionic liquid interactions, including areas of future interest.

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Section: Enzymesmentioning

confidence: 99%

Section: Enzymesmentioning

confidence: 99%

Proteins in Ionic Liquids: Reactions, Applications, and Futures

et al. 2019

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“…The same SILLP support was used for BCL immobilization, and applied in ethyl ester production from coconut oil. Further, a 70% conversion was achieved for oils after 144 h at 40 °C (coconut oil:ethanol, 1:7, molar ratio), when BCL–SILLP was used [ 93 ]. BCL lipase improved the activity of various phosphonium ILs.…”

Section: Supported Ionic Liquid Phases In Biocatalysismentioning

confidence: 99%

Ionic Liquids for Development of Heterogeneous Catalysts Based on Nanomaterials for Biocatalysis

Wolny

Chrobok

2021

Nanomaterials

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The development of effective methods of enzyme stabilization is key for the evolution of biocatalytic processes. An interesting approach combines the stabilization process of proteins in ionic liquids and the immobilization of the active phase on the solid support. As a result, stable, active and heterogeneous biocatalysts are obtained. There are several benefits associated with heterogeneous processes, as easy separation of the biocatalyst from the reaction mixture and the possibility of recycling. Accordingly, this work focused on the supported ionic liquid phases as the efficient enzyme stabilization carriers, and their application in both continuous flow and batch biocatalytic processes.

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“…Therefore, the search for biocatalysts with increased stability is one of the major challenges in the last decades. Among the several approaches used, the immobilization of enzymes by adsorption or covalent linking on solid supports, encapsulation into sol-gel matrices, among others, is a well-stablished and successful strategy to insolubilize and stabilize enzymes (BARBOSA et al, 2014;BARBOSA et al, 2016;DICOSIMO et al, 2013;KOPP et al, 2015;LISBOA et al, 2018;MANOEL et al, 2015;SANTANA et al, 2018;SARNO et al, 2017;VESCOVI et al, 2016;ŽIVKOVIĆ et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Hydrophobic immobilization of Burkholderia cepacia lipase onto octyl-silica for synthesis of flavors esters

Barbosa

Santos

Almeida

et al. 2020

BJD

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Burkholderia cepacia lipase (BCL) was immobilized onto silica modified with octyl groups (OS) and the biocatalyst (BCL-OS) was evaluated as its performance in the synthesis in organic medium (synthesis of flavor esters as a model). The maximum support loading was 0.375 genzyme/gsupport, yielding a biocatalyst with an activity of 1197 U/gsupport at pH 7.0 and 50 °C in the hydrolysis of olive oil. The biocatalyst BCL-OS showed to be 9-fold more stable than the free lipase at 60°C in buffer solution (absence of substrates), with an increase of half-life from 16 to 144 h. The physical-chemical characterization of silica, octyl silica, and BCL-OS biocatalyst allowed confirming the immobilization of BCL onto the modified silica. The biocatalyst had an excellent performance in the synthesis of flavor esters, yielding more than 85% esterification yield (based on acid consumption) for acetic and butyric acids as acyl donors, and ethanol, butanol and hexanol as acyl acceptors. The biocatalyst could be recycled by ten 5 h-cycles of butyl butyrate syntheses at 37°C in heptane, retaining around 80% of its initial activity. Therefore, these results indicate that the BCL immobilized onto silica modified with octyl groups is a promising biocatalyst for application in organic syntheses.

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New perspectives on the modification of silica aerogel particles with ionic liquid used in lipase immobilization with platform in ethyl esters production

Cited by 19 publications

References 43 publications

Proteins in Ionic Liquids: Reactions, Applications, and Futures

Proteins in Ionic Liquids: Reactions, Applications, and Futures

Ionic Liquids for Development of Heterogeneous Catalysts Based on Nanomaterials for Biocatalysis

Hydrophobic immobilization of Burkholderia cepacia lipase onto octyl-silica for synthesis of flavors esters

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