New perspectives on the reactions of metal nitrosyls with thiolates as nucleophiles

Souza, Maykon Lima; Roveda, Antonio C.; Pereira, Juliana da Silva; Franco, Douglas Wagner

doi:10.1016/j.ccr.2015.03.008

Cited by 19 publications

(13 citation statements)

References 127 publications

(347 reference statements)

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“…The lowest unoccupied molecular orbitals received electrons from the filled metal orbitals leading to formation of π-bond (Figure 13) [27,[32][33][34]. Therefore, there is the possibility of NO ligand present in NDMA forming complexes in Figures 14 and 15.…”

Section: π-Bond Formationmentioning

confidence: 99%

Application of chromatographic techniques in the analysis of total nitrosamines in water

Yahaya

Babatunde

Olaniyan

et al. 2020

Heliyon

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The use of ozone, chloramine and chlorine dioxide for water treatment results in the formation N-nitrosamines in the treated water. These groups of chemicals and other nitrogen-containing compounds have been described as disinfection by-products (DBPs) which are known for their toxicity. Nitrosamines are a potential source of nitric oxide (NO) which can bind with metals present in the sample matrix leading to formation of metalnitrosyl complexes and dissolved metals have the potential to increase the total nitrosamines in water. This phenomenon has not received the desired attention and determination of metal-nitrosyl complexes lack standard analytical technique. Chromatography linked to various detectors is the commonest of the techniques for nitrosamine analysis but it is beset with reduced sensitivity as a result of inappropriate choice of the column. Incidentally, chromatographic techniques have not been really adapted for the analysis of metal-nitrosyl complexes. Therefore, there is need for the survey of existing techniques vis-a-vis metal-nitrosamine analysis and to suggest possible areas for method optimization.

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Section: π-Bond Formationmentioning

confidence: 99%

Application of chromatographic techniques in the analysis of total nitrosamines in water

Yahaya

Babatunde

Olaniyan

et al. 2020

Heliyon

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“…34,62 The rate of this reaction is also extremely dependent of the concentration of H 3 O + , whereas at higher pH the reaction occurs faster. Due to this, we decided to work at pH 3.5, since it would slow down the reaction and make possible to follow the products by HPLC.…”

Section: Monitoring the Reaction Of The Nitrosyl Complex With Cysteinmentioning

confidence: 99%

“…29,34 It has been reported that when solutions of {MNO} 6 complexes are made alkaline, 36,40 a product with absorption band from 300 -400 nm is observed. 31,52,53 Additionally, this transformation is fully reversible upon addition of acid.…”

Section: (Imn)] + With Concomitant Production Of Cis-[ru(no)(bpy) 2 (mentioning

confidence: 99%

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Chromatographic Investigation of Ruthenium Nitrosyl Complex: No Interconversion and Reactions With Biological Reductants

Silva¹,

Penha²,

Alencar³

et al. 2018

Quim. Nova

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3 complex. Chromatographic studies were carried out and showed that immediately after nitrite complex was dissolved only one species was present with retention time(t R ) of 6.81 minutes. Addition of H 3 O + to nitrite complex led to the formation of one major peak with t R of 3.92 min supporting nitrosyl complex formation. The reaction of nitrosyl complex with cysteine was also monitored by HPLC and it showed clearly the formation and followed decrease of a peak at 3.38 minute with maximum absorption at 380 nm, consistent with an intermediate complex. Later, it was observed the appearance of a peak at 4.15 minute with absorption band at 470 nm. In contrast to the reaction with cysteine, methionine did not show the formation of any intermediate. The use of HPLC was an important tool to support mechanistic assumptions for nitrosyl reactions.

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“…Owing to these facts, we decided to coordinate the niacin ( Hnic ) molecule and its isomer, isonicotinic acid ( ina , Figure B), to ruthenium nitrosyl complex (nitric oxide donor) trans -[Ru(NO + )(NH 3 ) 4 (L)](BF 4 ) 3 (L = ina or Hnic ), Figure , to evaluate the analgesic and anti-inflammatory activities of these compounds in vivo . Complexes with the formula trans -[Ru(NO + )(NH 3 ) 4 (L)](BF 4 ) 3 release NO when triggered by light or by chemical reduction (through the reaction with chemical or biological reductants, such as cysteine and NADH). − Therefore, on the basis of this accumulated experimental evidence, this class of inorganic nitrosyls is considered to act as NO-donor compounds in vitro and in vivo . − ,− Pentaammine complexes [Ru(NH 3 ) 5 (L)](BF 4 ) 3 (L = ina or Hnic ) were synthesized because their structures are analogous to those of trans -[Ru(NO + )(NH 3 ) 4 (L)](BF 4 ) 3 , except for the coordinated NO; see Figure . This approach enables the comparison of the analgesic and anti-inflammatory activities of the NO-releasing complexes to those of the parent complex that does not release NO.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and Anti-nociceptive Activity of Ruthenium Complexes with Isonicotinic and Nicotinic Acids (Niacin) as Ligands

et al. 2015

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This work evaluated the analgesic and anti-inflammatory activity of ruthenium(II) complexes trans-[Ru(NO(+))(NH3)4(L)](BF4)3 and [Ru(NH3)5(L)](BF4)3 containing the nonsteroidal anti-inflammatory drugs nicotinic acid (Hnic) and its isomer isonicotinic acid (ina) as ligands (L). The anti-nociceptive potential of these complexes and the free ligands (noncoordinated to ruthenium) was tested in different models with doses ranging from 1 to 100 μmol/kg. The ligands themselves were inactive; however, the ruthenium complexes containing Hnic and ina inhibited mechanical hyperalgesia induced by prostaglandin E2, carrageenan-induced hyperalgesia, and antigen-induced arthritis. Moreover, the ruthenium complexes inhibited overt nociception induced by formalin, acetic acid, capsaicin, and cinnamaldehyde. The mechanism involved in the anti-nociceptive effects of the ruthenium complexes suggested that ATP-sensitive K(+) channel pathways were not involved because glibenclamide did not affect their anti-nociceptive activities. However, the anti-nociceptive effect appears to be a consequence of the reduction in neutrophil migration and inhibition of the protein kinase C pathway.

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New perspectives on the reactions of metal nitrosyls with thiolates as nucleophiles

Cited by 19 publications

References 127 publications

Application of chromatographic techniques in the analysis of total nitrosamines in water

Application of chromatographic techniques in the analysis of total nitrosamines in water

Chromatographic Investigation of Ruthenium Nitrosyl Complex: No Interconversion and Reactions With Biological Reductants

Anti-inflammatory and Anti-nociceptive Activity of Ruthenium Complexes with Isonicotinic and Nicotinic Acids (Niacin) as Ligands

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