New Perspectives on the Role of Nuclear Proteases in Cell Death Pathways

Frolova, Anastasia S.; Chepikova, Olga E.; Deviataikina, Anna S.; Solonkina, Alena D.; Zamyatnin, Andrey A.

doi:10.3390/biology12060797

Cited by 4 publications

(1 citation statement)

References 127 publications

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“…As a result of this phenomenon, recent studies have indicated that cathepsins can also translocate in the nucleus [95][96][97]. Interestingly, their activity within the nucleus appears to increase during apoptosis, even though more investigations are necessary to unveil the mechanisms underlying these phenomena [98]. Despite the role of ROS as a lysosome-permeabilizing agent, treatment of murine hepatoma cells with inhibitors of cathepsins L, B, and D did not prevent Bid activation after treatment with N-aspartyl chlorin e6 (NPe6) photosensitizer nanoparticles and subsequent irradiation [87].…”

Section: Interplay Between Ros and Cathepsins In Apoptosismentioning

confidence: 99%

The Intricate Balance between Life and Death: ROS, Cathepsins, and Their Interplay in Cell Death and Autophagy

Voronina,

Frolova,

Kolesova

et al. 2024

IJMS

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Cellular survival hinges on a delicate balance between accumulating damages and repair mechanisms. In this intricate equilibrium, oxidants, currently considered physiological molecules, can compromise vital cellular components, ultimately triggering cell death. On the other hand, cells possess countermeasures, such as autophagy, which degrades and recycles damaged molecules and organelles, restoring homeostasis. Lysosomes and their enzymatic arsenal, including cathepsins, play critical roles in this balance, influencing the cell’s fate toward either apoptosis and other mechanisms of regulated cell death or autophagy. However, the interplay between reactive oxygen species (ROS) and cathepsins in these life-or-death pathways transcends a simple cause-and-effect relationship. These elements directly and indirectly influence each other’s activities, creating a complex web of interactions. This review delves into the inner workings of regulated cell death and autophagy, highlighting the pivotal role of ROS and cathepsins in these pathways and their intricate interplay.

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Section: Interplay Between Ros and Cathepsins In Apoptosismentioning

confidence: 99%

The Intricate Balance between Life and Death: ROS, Cathepsins, and Their Interplay in Cell Death and Autophagy

Voronina,

Frolova,

Kolesova

et al. 2024

IJMS

Self Cite

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Elucidating the impact of parthanatos-related microRNAs on the tumoral immune microenvironment and clinical outcome in low-grade gliomas

Zhu,

Wu,

Zheng

et al. 2024

Discov Onc

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Parthanatos, a cell death mechanism triggered by PARP-1 activation, is implicated in oncogenic processes, yet their role in low-grade gliomas (LGG) remains poorly understood. This research investigates Parthanatos-related miRNAs' prognostic and immunomodulatory potential, alongside their influence on therapeutic outcomes in LGGs. Comprehensive miRNA and mRNA profiles of LGG patients were extracted from TCGA and CGGA databases, integrating clinical parameters to identify Parthanatos-associated miRNAs. IHC data validated the expression levels of Parthanatos-related genes in glioma versus normal brain tissues. Protein–protein interaction networks and Spearman correlation analysis facilitated the identification of key miRNAs. Parthanatos-related miRNA indices (PMI) were screened using Lasso and assessed for their accuracy in predicting prognosis, comparing their associated potential molecular functions and heterogeneity of the immune microenvironment. Drug sensitivity was assessed between different groups and optimal therapeutic agents were predicted. Validate the expression levels of key miRNAs by qPCR. Ninety-one miRNAs significantly associated with Parthanatos were screened, through which a PMI prognosis model of nine miRNAs was constructed. The PMI score was able to independently predict the prognosis of patients with LGG, and the nomogram constructed based on the PMI provided a practical tool for clinical prediction of patient prognosis. The proportion of immune response was lower in patients in the high-risk group, and there were significant differences in drug sensitivity between different risk classes, while drugs such as Fasudil were identified as the most promising therapeutic agents for patients in the high-risk group. Our findings highlight the critical role of Parthanatos-associated miRNAs in the progression and treatment of LGG, offering novel insights into their prognostic value and therapeutic potential.

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Proteases in DNA damage, repair, and radioresistance: Cellular and molecular aspects

Harsha,

Divya Lakshmanan

2025

Pathophysiological Aspects of Proteases in Cancer

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New Perspectives on the Role of Nuclear Proteases in Cell Death Pathways

Cited by 4 publications

References 127 publications

The Intricate Balance between Life and Death: ROS, Cathepsins, and Their Interplay in Cell Death and Autophagy

The Intricate Balance between Life and Death: ROS, Cathepsins, and Their Interplay in Cell Death and Autophagy

Elucidating the impact of parthanatos-related microRNAs on the tumoral immune microenvironment and clinical outcome in low-grade gliomas

Proteases in DNA damage, repair, and radioresistance: Cellular and molecular aspects

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