2021
DOI: 10.1002/chir.23376
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New pharmaceuticals approved by FDA in 2020: Small‐molecule drugs derived from amino acids and related compounds

Abstract: Amino acids (AAs) play an important role in the modern health industry as key synthetic precursors for pharmaceuticals, biomaterials, biosensors, and drug delivery systems. Currently, over 30% of small-molecule drugs contain residues of tailor-made AAs or derived from them amino-alcohols and diamines. In this review article, we profile 12 AA-derived new pharmaceuticals

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Cited by 33 publications
(22 citation statements)
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“…In the recent years, multiple 68 Ga-and 18 F-labelled PSMA-targeting radiotracers have been introduced and recommended in several guidelines (10)(11)(12). Furthermore, 68 Ga-PSMA-11 and 18 F-DCFPyL received recent FDA-approval for imaging of BCR (13,14).…”
Section: Psma-pet For Recurrent Pcamentioning
confidence: 99%
“…In the recent years, multiple 68 Ga-and 18 F-labelled PSMA-targeting radiotracers have been introduced and recommended in several guidelines (10)(11)(12). Furthermore, 68 Ga-PSMA-11 and 18 F-DCFPyL received recent FDA-approval for imaging of BCR (13,14).…”
Section: Psma-pet For Recurrent Pcamentioning
confidence: 99%
“…Tailor-made amino acids [1] play an indispensable role in the development of modern pharmaceuticals and drug formulations [2][3][4][5][6]. Thus, over 20% of newly approved smallmolecule drugs contain structural fragments of AAs [7][8][9]. In particular, γ-aminobutyricacid (GABA) derivatives bearing β-alkyl or β-aryl substituents, which include baclofen [10], phenibut [11][12][13], tolibut [14], and pregabalin [15][16][17], are recognized as an essential class of marketed pharmaceuticals for the treatment of neurological diseases (Figure 1).…”
Section: Introductionmentioning
confidence: 99%
“…The synthetic amino acid anti-1-amino-3-[ 18 F]-flurocyclobutane-1-carboxylic acid (namely, 18 F-FACBC, 18 F-fluciclovine, Axumin ® ) is an L-leucine analogue showing high tumor accumulation by addressing amino acid transports, which are up-regulated in PC [ 7 ]. On the other hand, PET/CT with ligands binding to Prostate Specific Membrane Antigen (PSMA), overexpressed by PC and only minimally detectable in normal prostate tissue, has recently been introduced with overwhelming results in clinical practice, and two PSMA-targeted radiopharmaceuticals have recently been FDA approved [ 8 , 9 ]. However, some PSMA ligands (e.g., 68 Ga-PSMA-11) show a meaningful accumulation in bladder; thus, the identification of loco-regional relapse might deserve particular attention and require dedicated protocols [ 10 ].…”
Section: Introductionmentioning
confidence: 99%