New phosphorus ylides in reactions of tertiary phosphines with phosphorylated quinone methide

Design, synthesis, and biological activity of novel ammonium salts containing sterically hindered phenolic fragment and phosphoryl group

“…[31][32][33] The main drawbacks of these approaches are the high temperatures of the reaction and the presence of catalysts, as well as the low yields of the products. A convenient approach for the synthesis of new derivatives of sterically hindered phenols that contain a phosphoryl fragment comprises the use of phosphorus-containing 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienones 34 in reactions with nucleophiles. Stable phosphorus-containing methylenequinones easily react with amines [35][36][37][38][39][40] and aminoacetals 41,42 to give the products of nucleophilic addition in high yields.…”