2022
DOI: 10.1016/j.coph.2022.102302
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New players of the adipose secretome: Therapeutic opportunities and challenges

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Cited by 4 publications
(2 citation statements)
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“…Alternatively, the thermogenic fat cells may have acted non-cell autonomously to remodel the adipose milieu in ways that limit immunocyte recruitment, reduce fibrosis, and promote insulin sensitivity 3,50 . Thermogenic fat cells can also engage in inter-organ signaling that improves glucose handling in distant organs 51 . In this regard, it is interesting to note that a SNP near the human RBM43 gene has been associated with type 2 diabetes in an African-American population 52 .…”
Section: Discussionmentioning
confidence: 99%
“…Alternatively, the thermogenic fat cells may have acted non-cell autonomously to remodel the adipose milieu in ways that limit immunocyte recruitment, reduce fibrosis, and promote insulin sensitivity 3,50 . Thermogenic fat cells can also engage in inter-organ signaling that improves glucose handling in distant organs 51 . In this regard, it is interesting to note that a SNP near the human RBM43 gene has been associated with type 2 diabetes in an African-American population 52 .…”
Section: Discussionmentioning
confidence: 99%
“…28 Adipose Tissue: Strategic Networking Through a Diverse Secretome Distinct classes of bioactive molecules are released by the adipose tissue, including peptide hormones, cytokines, enzymes, complement factors, growth factors, and chemokines (collectively referred to here as "adipokines"), and bioactive lipids (known as "lipokines"), which influence the metabolic, inflammatory, and immune landscape in normal physiology and disease. 25,30,31 Therefore, an altered adipose tissue secretory profile can affect core physiologic processes, locally or systemically, through an intricate signaling communication network, which includes not only classical adipokines and lipokines but also other mediators released by the adipose tissue, such as metabolites, noncoding RNAs, and exosomes. 25,[32][33][34] At the center of the adipose tissue regulatory network, adipokines represent an expanding class of cell signaling molecules that play a key role in energy homeostasis, inflammation, and immune response.…”
Section: Effect Of Obesity On Tumor Biology Development Of Cancer And...mentioning
confidence: 99%