Abstract:The present article endeavors to synthesize new polyamides via direct polycondensation of various diamines [hexamethylene diamine, q-phenylene diamine, 2,5-bis(m-aminobenzylidene) cyclopentanone, and 2,6-bis (m-aminobenzylidene)cyclohexanone] with different bis (carboxy-substituted) hydrazines such as [1,2-bis(3-carboxy acrylyl)hydrazine and 1,2-bis(3-carboxybenzoyl) hydrazine]. The polycondensation reaction of 1,2-bis(3-p-hydroxyanilide acrylyl) hydrazine with the same bis(carboxysubstituted) hydrazines gave … Show more
“…DSC curve of (CS-1) revealed an endothermic (Tg) at 105.77 °C and exothermic peak (Tc) at 325.89 °C. However, (DSC) curve of (CS-2) showed an endothermic glass transition temperature (Tg) at 111.25 °C, which increased than (CS-1), due to crosslinking with long aliphatic carbon chain of (PEGDGE) and increased the segmental motion of the chains 51 , 52 , and another exothermic peak crystalline temperature (Tc) at 295.48 °C. Figure 11 DSC of ( a ) (CS), ( b ) (CS-1), ( c ) (CS-2) and ( d ) (CS-3NPs).…”
Chitosan (CS) is a biopolymer that offers a wide range in biomedical applications due to its biocompatibility, biodegradability, low toxicity and antimicrobial activity. Syringaldehyde (1) is a naturally occurring organic compound characterized by its use in multiple fields such as pharmaceuticals, food, cosmetics, textiles and biological applications. Herein, development of chitosan derivative with physicochemical and anticancer properties via Schiff base formation from the reaction of chitosan with sustainable eco-friendly syringaldehyde yielded the (CS-1) derivative. Moreover, in the presence of polyethylene glycol diglycidyl ether (PEGDGE) or sodium tripolyphosphate (TPP) as crosslinkers gave chitosan derivatives (CS-2) and (CS-3NPs) respectively. The chemical structures of the new chitosan derivatives were confirmed using different tools. (CS-3NPs) nanoparticle showed improvement in crystallinity, and (CS-2) derivative revealed the highest thermal stability compared to virgin chitosan. The cytotoxicity activity of chitosan and its derivatives were evaluated against HeLa (human cervical carcinoma) and HEp-2 (Human Larynx carcinoma) cell lines. The highest cytotoxicity activity was exhibited by (CS-3NPs) compared to virgin chitosan against HeLa cell growth inhibition and apoptosis of 90.38 ± 1.46% and 30.3% respectively and IC50 of 108.01 ± 3.94 µg/ml. From the above results, it can be concluded that chitosan nanoparticle (CS-3NPs) has good therapeutic value as a potential antitumor agent against the HeLa cancer cell line.
“…DSC curve of (CS-1) revealed an endothermic (Tg) at 105.77 °C and exothermic peak (Tc) at 325.89 °C. However, (DSC) curve of (CS-2) showed an endothermic glass transition temperature (Tg) at 111.25 °C, which increased than (CS-1), due to crosslinking with long aliphatic carbon chain of (PEGDGE) and increased the segmental motion of the chains 51 , 52 , and another exothermic peak crystalline temperature (Tc) at 295.48 °C. Figure 11 DSC of ( a ) (CS), ( b ) (CS-1), ( c ) (CS-2) and ( d ) (CS-3NPs).…”
Chitosan (CS) is a biopolymer that offers a wide range in biomedical applications due to its biocompatibility, biodegradability, low toxicity and antimicrobial activity. Syringaldehyde (1) is a naturally occurring organic compound characterized by its use in multiple fields such as pharmaceuticals, food, cosmetics, textiles and biological applications. Herein, development of chitosan derivative with physicochemical and anticancer properties via Schiff base formation from the reaction of chitosan with sustainable eco-friendly syringaldehyde yielded the (CS-1) derivative. Moreover, in the presence of polyethylene glycol diglycidyl ether (PEGDGE) or sodium tripolyphosphate (TPP) as crosslinkers gave chitosan derivatives (CS-2) and (CS-3NPs) respectively. The chemical structures of the new chitosan derivatives were confirmed using different tools. (CS-3NPs) nanoparticle showed improvement in crystallinity, and (CS-2) derivative revealed the highest thermal stability compared to virgin chitosan. The cytotoxicity activity of chitosan and its derivatives were evaluated against HeLa (human cervical carcinoma) and HEp-2 (Human Larynx carcinoma) cell lines. The highest cytotoxicity activity was exhibited by (CS-3NPs) compared to virgin chitosan against HeLa cell growth inhibition and apoptosis of 90.38 ± 1.46% and 30.3% respectively and IC50 of 108.01 ± 3.94 µg/ml. From the above results, it can be concluded that chitosan nanoparticle (CS-3NPs) has good therapeutic value as a potential antitumor agent against the HeLa cancer cell line.
“…DSC curve of (CS-1) revealed an endothermic (Tg) at 105.77°C and exothermic peak (Tc) at 325.89°C. However, (DSC) curve of (CS-2) showed an endothermic glass transition temperature (Tg) at 111.25°C, which increased than (CS-1), due to crosslinking with long aliphatic carbon chain of (PEGDGE) and increased the segmental motion of the chains 47,48 , and another exothermic peak crystalline temperature (Tc) at 295.48°C.…”
Chitosan (CS) is a biopolymer offers a wide range in biomedical applications due to its biocompatibility, biodegradability, low toxicity and antimicrobial activity. Syringaldehyde (1) is naturally organic compound characterized by its uses in multiple fields such as pharmaceuticals, food, cosmetics, textiles and biological applications. Herein, development of chitosan physicochemical and anticancer properties via Schiff base formation from the reaction of chitosan with sustainable eco-friendly syringaldehyde yielded (CS-1) derivative. Moreover, in presence of polyethylene glycol diglycidyl ether (PEGDGE) or sodium tripolyphosphate (TPP) as crosslinkers gave chitosan derivatives (CS-2) and (CS-3NPs) respectively. The chemical structures of new chitosan derivatives are confirmed using different tools. (CS-3NPs) nanoparticle showed improvement in crystallinity, and (CS-2) derivative revealed the highest thermal stability compared to virgin chitosan. The cytotoxicity activity of chitosan and its derivatives is evaluated against HeLa (human cervical carcinoma) and HEp-2 (Human Larynx carcinoma) cell lines. The highest cytotoxicity activity is exhibited by (CS-3NPs) compared to virgin chitosan against HeLa cell growth inhibition and apoptosis of 90.38±1.46% and 30.3% respectively and IC50 of 108.01±3.94 µg/ml. From the above results, it can be concluded that chitosan nanoparticle (CS-3NPs) might be good therapeutic value as a potential antitumor agent against HeLa cancer cell line.
“…This study is extension of our previous work for the preparation of new modified polymers for different applications [33][34][35][36][37][38], polyvinyl alcohol was taken as the basic matrix and modified with two heterocyclic compounds [N,Nʹ-bi-α-azido succinimide (A) and N-phthalimido-α-azido succinimide (P)] via their reaction in the absence or presence of glutaraldehyde as a cross-linker to enhance the physicochemical properties of PVA. The prepared membranes were characterized using FTIR spectrum, X-ray, thermal analysis (TGA) and scanning electron microscopy (SEM).…”
Chemical modification of poly(vinyl alcohol) (PVA) with different monomers is a convention method for the development of its properties. In this study, the new multifunctional membranes (PVA-A)1–3, (PVA-P)1–3, (PVA-AG) and (PVA-PG) were designed and synthesized by the reaction of PVA with heterocyclic compounds [N,Nʹ-bi-α-azido succinimide (A), N-phthalimido-α-azido succinimide (P)] and using glutaraldehyde (G) as cross-linker, respectively. The new membranes were characterized by FT-IR, TGA, SEM and X-ray diffraction. The swelling behavior of the membranes showed that membranes (PVA-P)1–3 exhibited the highest swelling capacity in different solvents. Their antibacterial against (Gram-negative), (Gram-positive) bacteria, and in vitro drug loading and release activities were evaluated. Additionally, metal ions adsorption capacity for copper, cobalt and mercury ions was studied. (PVA-AG) membrane performed the highest inhibitory effect to E. coli, Proteus, S. aureus and B. subtilis bacteria reached 22.9, 25.46, 24.9 and 30.56, respectively. Furthermore, in vitro controlled loading and release of lidocaine, (PVA-A)1 membrane revealed remarkable ability reached 57.37% and 94.59%, respectively. Hydrogel (PVA-AG) showed the highest metal ions (copper, cobalt and mercury) uptake efficiency (64.5, 69.5 and 73), respectively. Based on results, the prepared membranes can be suggested as promising agents for antibacterial, drug delivery systems and metal ions removal from aqueous medium.
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